Risk Factors and Rate of Recurrence after Mohs Surgery in Basal Cell and Squamous Cell Carcinomas: A Nationwide Prospective Cohort (REGESMOHS, Spanish Registry of Mohs Surgery).
Journal
Acta dermato-venereologica
ISSN: 1651-2057
Titre abrégé: Acta Derm Venereol
Pays: Sweden
ID NLM: 0370310
Informations de publication
Date de publication:
24 Nov 2021
24 Nov 2021
Historique:
pubmed:
26
10
2021
medline:
27
11
2021
entrez:
25
10
2021
Statut:
epublish
Résumé
Randomized studies to assess the efficacy of Mohs micrographic surgery in basal cell and squamous cell carcinomas are limited by methodological and ethical issues and a lack of long follow-up periods. This study presents the "real-life" results of a nationwide 7-years cohort on basal cell carcinoma and squamous cell carcinoma treated with Mohs micrographic surgery. A prospective cohort was conducted in 22 Spanish centres (from July 2013 to February 2020) and a multivariate analysis, including characteristics of patients, tumours, surgeries and follow-up, was performed. A total of 4,402 patients followed up for 12,111 patient-years for basal cell carcinoma, and 371 patients with 915 patient-years of follow-up for squamous cell carcinoma were recruited. Risk factors for recurrence included age, non-primary tumours and more stages or unfinished surgeries for both tumours, and immunosuppression for squamous cell carcinoma. Incidence rates of recurrence were 1.3 per 100 person-years for basal cell carcinoma (95% confidence interval 1.1-1.5) and 4.5 for squamous cell carcinoma (95% confidence interval 3.3-6.1), being constant over time (0-5 years). In conclusion, follow-up strategies should be equally intense for at least the first 5 years, with special attention paid to squamous cell carcinoma (especially in immunosuppressed patients), elderly patients, non-primary tumours, and those procedures requiring more stages, or unfinished surgeries.
Identifiants
pubmed: 34694418
doi: 10.2340/actadv.v101.544
pmc: PMC9455311
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
adv00602Références
J Am Acad Dermatol. 2005 Aug;53(2):261-6
pubmed: 16021121
Head Neck Surg. 1978 Nov-Dec;1(2):150-66
pubmed: 755808
Br J Dermatol. 2004 Jul;151(1):141-7
pubmed: 15270883
J Am Acad Dermatol. 2005 Sep;53(3):445-51
pubmed: 16112351
Lancet. 2004 Nov 13-19;364(9447):1766-72
pubmed: 15541449
Eur J Cancer. 2014 Nov;50(17):3011-20
pubmed: 25262378
J Invest Dermatol. 2017 Nov;137(11):2309-2315
pubmed: 28736229
Eur J Cancer. 2019 Sep;118:10-34
pubmed: 31288208
J Am Acad Dermatol. 2005 Aug;53(2):253-60
pubmed: 16021120
J Dermatol Surg Oncol. 1981 Oct;7(10):779-89
pubmed: 7298977
Br J Dermatol. 2012 May;166(5):1069-80
pubmed: 22251204
J Dermatol Surg Oncol. 1978 Jan;4(1):41-54
pubmed: 618934
J Am Acad Dermatol. 1998 Jul;39(1):79-97
pubmed: 9674401
J Am Acad Dermatol. 2012 Oct;67(4):531-50
pubmed: 22959232
Photochem Photobiol. 2010 May-Jun;86(3):481-91
pubmed: 20550646
Arch Dermatol. 1982 Nov;118(11):900-2
pubmed: 7138046
J Am Acad Dermatol. 1992 Jun;26(6):976-90
pubmed: 1607418
Actas Dermosifiliogr. 2016 May;107(4):318-28
pubmed: 26852370
Dermatol Surg. 2010 Oct;36(10):1544-53
pubmed: 21053415
J Am Acad Dermatol. 2018 Feb;78(2):237-247
pubmed: 29332704
Actas Dermosifiliogr. 2015 Sep;106(7):562-8
pubmed: 26028578
J Am Acad Dermatol. 2020 Jan;82(1):139-148
pubmed: 31279037
Int J Dermatol. 2018 Nov;57(11):1375-1381
pubmed: 30246444
Actas Dermosifiliogr. 2015 Nov;106(9):764-6
pubmed: 26115794
Lancet Oncol. 2008 Dec;9(12):1149-56
pubmed: 19010733
J Eur Acad Dermatol Venereol. 2012 Jul;26(7):838-43
pubmed: 21707774
Dermatol Surg. 2009 Sep;35(9):1349-54
pubmed: 19500127
J Am Acad Dermatol. 2005 Sep;53(3):452-7
pubmed: 16112352
Br J Dermatol. 2019 May;180(5):1176-1182
pubmed: 30536656
J Am Acad Dermatol. 1998 Jun;38(6 Pt 1):960-6
pubmed: 9632005
Ann Intern Med. 2018 Oct 2;169(7):456-466
pubmed: 30242379
Br J Dermatol. 1997 Apr;136(4):515-8
pubmed: 9155950
Br J Dermatol. 2019 Aug;181(2):233-234
pubmed: 31368521
J Am Acad Dermatol. 2019 Mar;80(3):633-638
pubmed: 30244064