Biological and Clinical Factors Contributing to the Metabolic Heterogeneity of Hospitalized Patients with and without COVID-19.
Acute Disease
Adult
Amino Acids
/ blood
Body Mass Index
COVID-19
/ metabolism
Carnitine
/ analogs & derivatives
Cohort Studies
Fatty Acids
/ blood
Female
Humans
Kynurenine
/ blood
Machine Learning
Metabolomics
Middle Aged
Prognosis
Prospective Studies
SARS-CoV-2
/ isolation & purification
Severity of Illness Index
Tryptophan
/ blood
COVID-19
acylcarnitine
amino acid
fatty acid
kynurenine
metabolomics
tryptophan
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
02 09 2021
02 09 2021
Historique:
received:
14
07
2021
revised:
24
08
2021
accepted:
31
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
9
10
2021
Statut:
epublish
Résumé
The Corona Virus Disease 2019 (COVID-19) pandemic represents an ongoing worldwide challenge. The present large study sought to understand independent and overlapping metabolic features of samples from acutely ill patients (n = 831) that tested positive (n = 543) or negative (n = 288) for COVID-19. High-throughput metabolomics analyses were complemented with antigen and enzymatic activity assays on plasma from acutely ill patients collected while in the emergency department, at admission, or during hospitalization. Lipidomics analyses were also performed on COVID-19-positive or -negative subjects with the lowest and highest body mass index (n = 60/group). Significant changes in amino acid and fatty acid/acylcarnitine metabolism emerged as highly relevant markers of disease severity, progression, and prognosis as a function of biological and clinical variables in these patients. Further, machine learning models were trained by entering all metabolomics and clinical data from half of the COVID-19 patient cohort and then tested on the other half, yielding ~78% prediction accuracy. Finally, the extensive amount of information accumulated in this large, prospective, observational study provides a foundation for mechanistic follow-up studies and data sharing opportunities, which will advance our understanding of the characteristics of the plasma metabolism in COVID-19 and other acute critical illnesses.
Identifiants
pubmed: 34571942
pii: cells10092293
doi: 10.3390/cells10092293
pmc: PMC8467961
pii:
doi:
Substances chimiques
Amino Acids
0
Fatty Acids
0
acylcarnitine
0
Kynurenine
343-65-7
Tryptophan
8DUH1N11BX
Carnitine
S7UI8SM58A
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : RM1GM131968
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01HL146442
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01HL149714
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01HL148151
Pays : United States
Organisme : NHLBI NIH HHS
ID : R21HL150032
Pays : United States
Commentaires et corrections
Type : UpdateOf
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