BLMP-1 promotes developmental cell death in C. elegans by timely repression of ced-9 transcription.
Caenorhabditis elegans
BLMP-1/Blimp1
CED-9/BCL2
Developmental timing
Programmed cell death
Journal
Development (Cambridge, England)
ISSN: 1477-9129
Titre abrégé: Development
Pays: England
ID NLM: 8701744
Informations de publication
Date de publication:
15 10 2021
15 10 2021
Historique:
received:
17
06
2020
accepted:
14
09
2021
pubmed:
21
9
2021
medline:
15
12
2021
entrez:
20
9
2021
Statut:
ppublish
Résumé
Programmed cell death (PCD) is a common cell fate in metazoan development. PCD effectors are extensively studied, but how they are temporally regulated is less understood. Here, we report a mechanism controlling tail-spike cell death onset during Caenorhabditis elegans development. We show that the zinc-finger transcription factor BLMP-1, which controls larval development timing, also regulates embryonic tail-spike cell death initiation. BLMP-1 functions upstream of CED-9 and in parallel to DRE-1, another CED-9 and tail-spike cell death regulator. BLMP-1 expression is detected in the tail-spike cell shortly after the cell is born, and blmp-1 mutations promote ced-9-dependent tail-spike cell survival. BLMP-1 binds ced-9 gene regulatory sequences, and inhibits ced-9 transcription just before cell-death onset. BLMP-1 and DRE-1 function together to regulate developmental timing, and their mammalian homologs regulate B-lymphocyte fate. Our results, therefore, identify roles for developmental timing genes in cell-death initiation, and suggest conservation of these functions.
Identifiants
pubmed: 34541605
pii: 272221
doi: 10.1242/dev.193995
pmc: PMC8572009
pii:
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Repressor Proteins
0
blmp-1 protein, C elegans
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NICHD NIH HHS
ID : F32 HD089640
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS105094
Pays : United States
Informations de copyright
© 2021. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interests The authors declare no competing or financial interests.
Références
Methods Cell Biol. 1995;48:451-82
pubmed: 8531738
Nat Rev Immunol. 2007 Dec;7(12):923-7
pubmed: 17965637
Science. 1998 Aug 28;281(5381):1355-7
pubmed: 9721101
Development. 2003 Sep;130(17):4057-71
pubmed: 12874127
Mol Cell Biol. 2007 Dec;27(24):8739-47
pubmed: 17923694
Cell Rep. 2018 Jul 10;24(2):391-405
pubmed: 29996100
J Biol Chem. 1998 Dec 11;273(50):33495-500
pubmed: 9837929
Nat Methods. 2009 May;6(5):343-5
pubmed: 19363495
Genes Dev. 1991 May;5(5):868-79
pubmed: 1851123
Cell. 1994 Jul 15;78(1):9
pubmed: 8033216
Dev Biol. 1977 Mar;56(1):110-56
pubmed: 838129
Dev Cell. 2007 Jan;12(1):73-86
pubmed: 17199042
Cell Death Differ. 2017 Aug;24(8):1326-1336
pubmed: 28211869
Dev Cell. 2017 Jun 19;41(6):665-673.e6
pubmed: 28602583
Dev Cell. 2007 Mar;12(3):443-55
pubmed: 17336909
Dev Biol. 2001 Jan 1;229(1):71-88
pubmed: 11133155
Cancer Lett. 2015 Jun 28;362(1):70-82
pubmed: 25827072
J Biol Chem. 2000 Sep 1;275(35):27205-11
pubmed: 10846174
Cancer Res. 2007 Dec 15;67(24):11914-23
pubmed: 18089822
Cell. 1993 Nov 19;75(4):641-52
pubmed: 8242740
Mol Cell. 1999 Sep;4(3):309-19
pubmed: 10518212
Cell. 2011 Nov 11;147(4):742-58
pubmed: 22078876
Cell. 1998 May 15;93(4):519-29
pubmed: 9604928
Development. 2007 Apr;134(7):1357-68
pubmed: 17329362
Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10585-90
pubmed: 21670299
Cell. 1994 Apr 22;77(2):297-306
pubmed: 8168136
Eur J Immunol. 1999 Sep;29(9):2988-98
pubmed: 10508273
PLoS Genet. 2014 Jun 26;10(6):e1004428
pubmed: 24968003
Genetics. 2016 Aug;203(4):1533-62
pubmed: 27516615
Dev Cell. 2014 Mar 31;28(6):697-710
pubmed: 24613396
Dev Biol. 1983 Nov;100(1):64-119
pubmed: 6684600
Cell. 1994 Feb 25;76(4):665-76
pubmed: 7907274
J Exp Med. 1998 Aug 3;188(3):515-25
pubmed: 9687529
J Vis Exp. 2013 Dec 09;(82):e50773
pubmed: 24379027
Nature. 2003 Jan 16;421(6920):231-7
pubmed: 12529635
Genetics. 1974 May;77(1):71-94
pubmed: 4366476
Nature. 1998 Feb 19;391(6669):806-11
pubmed: 9486653
Nature. 2012 Jan 5;481(7379):90-3
pubmed: 22113614
Annu Rev Immunol. 2018 Apr 26;36:489-517
pubmed: 29400998
Science. 2000 Feb 25;287(5457):1485-9
pubmed: 10688797
Dev Biol. 2006 Dec 15;300(2):623-34
pubmed: 16949569
Nat Cell Biol. 2018 Apr;20(4):393-399
pubmed: 29556089
Science. 2010 Dec 24;330(6012):1775-87
pubmed: 21177976
Curr Biol. 2021 Feb 22;31(4):809-826.e6
pubmed: 33357451
Cell Death Differ. 2013 May;20(5):669-75
pubmed: 23449394
Dev Genes Evol. 2006 May;216(5):243-52
pubmed: 16506071
Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3943-8
pubmed: 23431138
Elife. 2014 Dec 30;3:e04265
pubmed: 25432023