Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia.
Journal
Nature cancer
ISSN: 2662-1347
Titre abrégé: Nat Cancer
Pays: England
ID NLM: 101761119
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
entrez:
30
8
2021
pubmed:
31
8
2021
medline:
31
8
2021
Statut:
ppublish
Résumé
RNA binding proteins (RBPs) are key arbiters of post-transcriptional regulation and are found to be found dysregulated in hematological malignancies. Here, we identify the RBP RBMX and its retrogene RBMXL1 to be required for murine and human myeloid leukemogenesis. RBMX/L1 are overexpressed in acute myeloid leukemia (AML) primary patients compared to healthy individuals, and RBMX/L1 loss delayed leukemia development. RBMX/L1 loss lead to significant changes in chromatin accessibility, as well as chromosomal breaks and gaps. We found that RBMX/L1 directly bind to mRNAs, affect transcription of multiple loci, including
Identifiants
pubmed: 34458856
doi: 10.1038/s43018-021-00220-w
pmc: PMC8388313
mid: NIHMS1703553
doi:
Substances chimiques
Chromatin
0
Heterogeneous-Nuclear Ribonucleoproteins
0
RBMX protein, human
0
RNA-Binding Proteins
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
741-757Subventions
Organisme : NCI NIH HHS
ID : R01 CA186702
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA193842
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA225231
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK101989
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01 DK084261
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL135564
Pays : United States
Références
Cell Stem Cell. 2019 Jan 3;24(1):153-165.e7
pubmed: 30472158
Nucleic Acids Res. 2014 Jun;42(10):6659-72
pubmed: 24692659
Nat Commun. 2019 Oct 10;10(1):4596
pubmed: 31601799
Leukemia. 2013 Mar;27(3):629-34
pubmed: 23047475
Nature. 2020 Jul;583(7816):431-436
pubmed: 32581360
Nat Commun. 2019 Jun 19;10(1):2691
pubmed: 31217428
Nature. 2018 Sep;561(7721):132-136
pubmed: 30150775
Oncotarget. 2017 Sep 24;8(49):84743-84760
pubmed: 29156680
Cell. 2019 Jun 27;178(1):107-121.e18
pubmed: 31251911
Int J Biochem Cell Biol. 2019 Mar;108:1-6
pubmed: 30593955
Cell Rep. 2014 Jul 10;8(1):75-83
pubmed: 24981864
Mol Cell. 2015 Mar 5;57(5):936-947
pubmed: 25747659
Mol Cell. 2017 Dec 21;68(6):1023-1037.e15
pubmed: 29272703
Nucleus. 2010 Jan-Feb;1(1):109-22
pubmed: 21327109
Oncotarget. 2016 Apr 5;7(14):18736-49
pubmed: 26934650
Cancer Cell. 2019 Mar 18;35(3):369-384.e7
pubmed: 30799057
Science. 1998 Apr 24;280(5363):585-90
pubmed: 9554849
Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7189-94
pubmed: 26015579
Cell Rep. 2012 Apr 19;1(4):299-308
pubmed: 22832223
Mol Biol Cell. 2007 Mar;18(3):755-67
pubmed: 17182846
Curr Opin Struct Biol. 2019 Oct;58:88-96
pubmed: 31252218
Cold Spring Harb Perspect Med. 2020 May 1;10(5):
pubmed: 31615866
Nat Commun. 2016 Jul 27;7:12248
pubmed: 27461529
Nat Genet. 2017 Jun;49(6):866-875
pubmed: 28436985
Biochem Biophys Res Commun. 2012 Sep 28;426(3):299-305
pubmed: 22902925
Hum Mol Genet. 2003 Jun 1;12(11):1337-48
pubmed: 12761049
J Cell Physiol. 2019 Nov;234(11):20322-20328
pubmed: 31344987
Leukemia. 2002 Nov;16(11):2339-41
pubmed: 12399985
Nat Chem Biol. 2017 Jun;13(6):675-680
pubmed: 28437394
Nature. 2010 Aug 5;466(7307):765-8
pubmed: 20639863
Cancer Res. 2009 Apr 15;69(8):3347-55
pubmed: 19351840
Science. 2017 Apr 28;356(6336):
pubmed: 28302793
Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2794-9
pubmed: 16477019
Lung Cancer. 2014 Aug;85(2):168-74
pubmed: 24954872
Front Med. 2018 Jun;12(3):280-288
pubmed: 29185122
Science. 1994 Sep 2;265(5177):1442-5
pubmed: 8073286
J Mol Biol. 2018 Nov 2;430(23):4650-4665
pubmed: 29913160
Nucleic Acids Res. 2017 Jun 2;45(10):6051-6063
pubmed: 28334903
Blood. 2003 Feb 15;101(4):1551-7
pubmed: 12393509
Nat Commun. 2016 Feb 22;7:10739
pubmed: 26898884
Cell. 2017 Feb 23;168(5):890-903.e15
pubmed: 28162770
Genome Res. 2016 Jan;26(1):97-107
pubmed: 26537359
Nat Struct Mol Biol. 2011 Apr;18(4):443-50
pubmed: 21399644
Nat Med. 2017 Nov;23(11):1369-1376
pubmed: 28920958
Nat Med. 2010 Aug;16(8):903-8
pubmed: 20616797
Haematologica. 2011 Jan;96(1):55-61
pubmed: 20971817
Nature. 2001 Mar 1;410(6824):120-4
pubmed: 11242054
Mol Cell. 2012 Jun 8;46(5):674-90
pubmed: 22681889
Cell Stem Cell. 2009 Feb 6;4(2):129-40
pubmed: 19200802
Clin Cancer Res. 2006 May 15;12(10):3222-8
pubmed: 16707624
Cell. 2015 Sep 24;163(1):123-33
pubmed: 26406374
Elife. 2016 Jan 29;5:e12175
pubmed: 26824388
BMC Cancer. 2015 Feb 27;15:86
pubmed: 25884434
Mol Cell Biol. 2014 Apr;34(7):1300-9
pubmed: 24469397
J Clin Invest. 2015 Mar 2;125(3):1286-98
pubmed: 25664853
Nature. 2018 Oct;562(7728):526-531
pubmed: 30333627
Cell. 2012 May 11;149(4):753-67
pubmed: 22579281
Mol Cell. 2015 Feb 5;57(3):552-8
pubmed: 25601759
Nat Rev Mol Cell Biol. 2004 Apr;5(4):296-304
pubmed: 15071554
Genome Biol. 2008;9(9):R137
pubmed: 18798982
Nat Chem Biol. 2007 Sep;3(9):570-5
pubmed: 17643112
ACS Chem Biol. 2011 Jun 17;6(6):582-9
pubmed: 21344922
Nat Chem Biol. 2007 Sep;3(9):576-83
pubmed: 17643111
J Biol Chem. 2009 May 22;284(21):14303-15
pubmed: 19282290
Cell Stem Cell. 2015 Aug 6;17(2):152-164
pubmed: 26212080
Nat Rev Drug Discov. 2012 Nov;11(11):847-59
pubmed: 23123942
Int J Cancer. 2011 May 1;128(9):2010-9
pubmed: 20607830
Blood. 2011 Sep 8;118(10):2857-67
pubmed: 21753187
Leuk Res. 2010 May;34(5):615-21
pubmed: 19748670
J Cell Biochem. 2006 Apr 15;97(6):1275-82
pubmed: 16552754
Mol Cell. 2019 Oct 3;76(1):70-81.e9
pubmed: 31445886
Mol Cells. 2008 Sep 30;26(3):217-27
pubmed: 18664736
Nature. 2016 Dec 15;540(7633):433-437
pubmed: 27926740
Nucleic Acids Res. 2019 Jan 25;47(2):570-581
pubmed: 30517751
Mamm Genome. 2001 Jul;12(7):538-45
pubmed: 11420617
Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):E5593-601
pubmed: 25480548
Cell. 2021 May 27;184(11):2878-2895.e20
pubmed: 33979654
Cell. 2018 Oct 18;175(3):835-847.e25
pubmed: 30340044