Natural rubber dressing loaded with silver sulfadiazine for the treatment of burn wounds infected with Candida spp.
Animals
Antifungal Agents
/ pharmacology
Bandages
Burns
/ drug therapy
Candida
/ drug effects
Fibroblasts
/ drug effects
Hemolysis
/ drug effects
Kinetics
Mice
Microbial Sensitivity Tests
NIH 3T3 Cells
Rubber
/ pharmacology
Sheep
Silver Sulfadiazine
/ chemistry
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
Antimicrobial
Biomaterial
Biopolymer
Dressing
Natural rubber latex
Silver sulfadiazine
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
31 Oct 2021
31 Oct 2021
Historique:
received:
21
04
2021
revised:
07
08
2021
accepted:
12
08
2021
pubmed:
22
8
2021
medline:
17
12
2021
entrez:
21
8
2021
Statut:
ppublish
Résumé
Millions of people are burned worldwide every year and 265,000 of the cases are fatal. The development of burn treatment cannot consist only of the administration of a single drug. Due to the infection risk, antibiotics are used in conjunction with gels and damp bandages. In this work, an inexpensive curative based on silver sulfadiazine (SS) and natural rubber latex (NRL) was developed to treat burn wounds. It was produced by the casting method. The infrared spectrum presented no interaction between drug and biopolymer. At the same time, electronic micrographs showed that the SS crystals are inserted on the polymeric dressing surface. Mechanical properties after the drug incorporation were considered suitable for dermal application. About 32.4% of loaded SS was released in 192 h by the dressings that also inhibited the growth of Candida albicans and Candida parapsilosis at 75.0 and 37.5 μg·mL
Identifiants
pubmed: 34418421
pii: S0141-8130(21)01761-X
doi: 10.1016/j.ijbiomac.2021.08.102
pii:
doi:
Substances chimiques
Antifungal Agents
0
Rubber
9006-04-6
Silver Sulfadiazine
W46JY43EJR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
597-606Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.