Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin.

Activins / metabolism Animals Cell Proliferation Cell Transdifferentiation Drosophila Proteins / genetics Drosophila melanogaster Follistatin / metabolism Male Spermatozoa / cytology Stem Cell Niche Testis / cytology Transcription Factors / genetics
Activin Dp/E2f Drosophila Follistatin aging cyst stem cell fertility niche quiescence testis transdifferentiation

Journal

Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028

Informations de publication

Date de publication:
23 08 2021
Historique:
received: 22 01 2021
revised: 14 05 2021
accepted: 15 07 2021
pubmed: 8 8 2021
medline: 18 11 2021
entrez: 7 8 2021
Statut: ppublish

Résumé

Aging causes stem cell dysfunction as a result of extrinsic and intrinsic changes. Decreased function of the stem cell niche is an important contributor to this dysfunction. We use the Drosophila testis to investigate what factors maintain niche cells. The testis niche comprises quiescent "hub" cells and supports two mitotic stem cell pools: germline stem cells and somatic cyst stem cells (CySCs). We identify the cell-cycle-responsive Dp/E2f1 transcription factor as a crucial non-autonomous regulator required in CySCs to maintain hub cell quiescence. Dp/E2f1 inhibits local Activin ligands through production of the Activin antagonist Follistatin (Fs). Inactivation of Dp/E2f1 or Fs in CySCs or promoting Activin receptor signaling in hub cells causes transdifferentiation of hub cells into fully functional CySCs. This Activin-dependent communication between CySCs and hub regulates the physiological decay of the niche with age and demonstrates that hub cell quiescence results from signals from surrounding stem cells.

Identifiants

DOI: 10.1016/j.devcel.2021.07.010 PMID: 34363758 PMC: PMC8387025
pubmed: 34363758
pii: S1534-5807(21)00593-1
doi: 10.1016/j.devcel.2021.07.010
pmc: PMC8387025
mid: NIHMS1734671
pii:
doi:

Substances chimiques

Drosophila Proteins 0
E2f1 protein, Drosophila 0
Follistatin 0
Transcription Factors 0
Activins 104625-48-1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

2284-2294.e6

Subventions

Organisme : Medical Research Council
ID : MR/P009646/1
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : R01 GM085075
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM066704
Pays : United States
Organisme : Medical Research Council
ID : MR/P009646/2
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

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Auteurs

Salvador C Herrera (SC)

Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA; Centro Andaluz de Biología del Desarrollo, CSIC/Universidad Pablo de Olavide/JA, Carretera de Utrera km 1, 41013 Sevilla, Spain.

Diego Sainz de la Maza (D)

Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.

Lydia Grmai (L)

Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.

Shally Margolis (S)

Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.

Rebecca Plessel (R)

Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.

Michael Burel (M)

Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.

Michael O'Connor (M)

Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.

Marc Amoyel (M)

Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: marc.amoyel@ucl.ac.uk.

Erika A Bach (EA)

Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA. Electronic address: erika.bach@nyu.edu.

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Classifications MeSH

Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Activines › Proliferative stem cells maintain quiescence...
Recherchemedicale.com › Eucaryotes › Animaux › Proliferative stem cells maintain quiescence...
Recherchemedicale.com › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Proliferative stem cells maintain quiescence...
Recherchemedicale.com › Phénomènes physiologiques cellulaires › Transdifférenciation cellulaire › Proliferative stem cells maintain quiescence...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines d'arthropode › Protéines d'insecte › Protéines de Drosophila › Proliferative stem cells maintain quiescence...
Recherchemedicale.com › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › Proliferative stem cells maintain quiescence...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Follistatine › Proliferative stem cells maintain quiescence...
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