Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome.
Adult
Alzheimer Disease
/ blood
Amyloid beta-Peptides
/ metabolism
Area Under Curve
Atrophy
Biomarkers
/ blood
Cerebral Cortex
/ diagnostic imaging
Cognition
Cross-Sectional Studies
Disease Progression
Down Syndrome
/ blood
Female
Humans
Male
Middle Aged
Neurofilament Proteins
/ blood
Phosphorylation
tau Proteins
/ blood
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
14 07 2021
14 07 2021
Historique:
received:
26
10
2020
accepted:
09
06
2021
entrez:
15
7
2021
pubmed:
16
7
2021
medline:
28
7
2021
Statut:
epublish
Résumé
Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer's disease (AD) pathology with high accuracy in the general population. In this study, we investigated plasma p-tau181 as a biomarker of AD in individuals with Down syndrome (DS). We included 366 adults with DS (240 asymptomatic, 43 prodromal AD, 83 AD dementia) and 44 euploid cognitively normal controls. We measured plasma p-tau181 with a Single molecule array (Simoa) assay. We examined the diagnostic performance of p-tau181 for the detection of AD and the relationship with other fluid and imaging biomarkers. Plasma p-tau181 concentration showed an area under the curve of 0.80 [95% CI 0.73-0.87] and 0.92 [95% CI 0.89-0.95] for the discrimination between asymptomatic individuals versus those in the prodromal and dementia groups, respectively. Plasma p-tau181 correlated with atrophy and hypometabolism in temporoparietal regions. Our findings indicate that plasma p-tau181 concentration can be useful to detect AD in DS.
Identifiants
pubmed: 34262030
doi: 10.1038/s41467-021-24319-x
pii: 10.1038/s41467-021-24319-x
pmc: PMC8280160
doi:
Substances chimiques
Amyloid beta-Peptides
0
Biomarkers
0
Neurofilament Proteins
0
tau Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4304Subventions
Organisme : Medical Research Council
ID : MR/S005145/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R21 AG056974
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG056850
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG061566
Pays : United States
Informations de copyright
© 2021. The Author(s).
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