Regulatory Dendritic Cells Induced by Bendamustine Are Associated With Enhanced Flt3 Expression and Alloreactive T-Cell Death.
Animals
Apoptosis
/ immunology
Bendamustine Hydrochloride
/ pharmacology
CD4-Positive T-Lymphocytes
/ immunology
Dendritic Cells
/ drug effects
Female
Graft vs Host Disease
/ immunology
Humans
Lymphocyte Activation
/ immunology
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Transplantation Conditioning
/ methods
fms-Like Tyrosine Kinase 3
/ immunology
Alloreactivity
Flt3
Regulatory DC
bendamustine
dendritic cell
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
04
2021
accepted:
14
06
2021
entrez:
12
7
2021
pubmed:
13
7
2021
medline:
15
12
2021
Statut:
epublish
Résumé
The growth factor Flt3 ligand (Flt3L) is central to dendritic cell (DC) homeostasis and development, controlling survival and expansion by binding to Flt3 receptor tyrosine kinase on the surface of DCs. In the context of hematopoietic cell transplantation, Flt3L has been found to suppress graft-versus-host disease (GvHD), specifically
Identifiants
pubmed: 34249005
doi: 10.3389/fimmu.2021.699128
pmc: PMC8264365
doi:
Substances chimiques
Bendamustine Hydrochloride
981Y8SX18M
fms-Like Tyrosine Kinase 3
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
699128Informations de copyright
Copyright © 2021 Molina, Hoffman, Stokes, Kummet, Smith, Baker, Zúñiga, Simpson and Katsanis.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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