Large Animal Models for Investigating Cell Therapies of Stress Urinary Incontinence.
animal
cell therapy
disease models
urinary incontinence
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
05 Jun 2021
05 Jun 2021
Historique:
received:
12
04
2021
revised:
28
05
2021
accepted:
31
05
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
15
7
2021
Statut:
epublish
Résumé
Stress urinary incontinence (SUI) is a significant health concern for patients affected, impacting their quality of life severely. To investigate mechanisms contributing to SUI different animal models were developed. Incontinence was induced under defined conditions to explore the pathomechanisms involved, spontaneous recovery, or efficacy of therapies over time. The animal models were coined to mimic known SUI risk factors such as childbirth or surgical injury. However, animal models neither reflect the human situation completely nor the multiple mechanisms that ultimately contribute to the pathogenesis of SUI. In the past, most SUI animal studies took advantage of rodents or rabbits. Recent models present for instance transgenic rats developing severe obesity, to investigate metabolic interrelations between the disorder and incontinence. Using recombinant gene technologies, such as transgenic, gene knock-out or CRISPR-Cas animals may narrow the gap between the model and the clinical situation of patients. However, to investigate surgical regimens or cell therapies to improve or even cure SUI, large animal models such as pig, goat, dog and others provide several advantages. Among them, standard surgical instruments can be employed for minimally invasive transurethral diagnoses and therapies. We, therefore, focus in this review on large animal models of SUI.
Identifiants
pubmed: 34198749
pii: ijms22116092
doi: 10.3390/ijms22116092
pmc: PMC8201285
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : KFO273
Organisme : Deutsche Forschungsgemeinschaft
ID : PoTuS
Organisme : BMBF
ID : Multimorb-INKO
Organisme : EU
ID : MUS.I.C.
Références
Stem Cell Res Ther. 2016 Oct 7;7(1):147
pubmed: 27717380
Neurourol Urodyn. 2004;23(2):166-71
pubmed: 14983430
J Urol. 2013 Nov;190(5):1938-45
pubmed: 23618586
Int J Urol. 2016 Aug;23(8):701-5
pubmed: 27225822
World J Urol. 2017 Dec;35(12):1977-1986
pubmed: 28940030
Handb Exp Pharmacol. 2011;(202):45-67
pubmed: 21290221
Int J Urol. 1999 Jan;6(1):33-7
pubmed: 10221862
Adv Drug Deliv Rev. 2015 Mar;82-83:106-16
pubmed: 25453264
Am J Obstet Gynecol. 2001 Dec;185(6):1318-23; discussion 1323-4
pubmed: 11744903
J Urol. 2009 Jan;181(1):397-400
pubmed: 19010492
Int Neurourol J. 2012 Sep;16(3):102-6
pubmed: 23094214
Anat Embryol (Berl). 2003 May;206(6):429-35
pubmed: 12728313
Anat Histol Embryol. 2004 Dec;33(6):355-61
pubmed: 15540995
Neurourol Urodyn. 2011 Jun;30(5):636-46
pubmed: 21661007
Stem Cells Dev. 2013 Jan 15;22(2):340-4
pubmed: 22913652
BJU Int. 2017 Feb;119(2):317-324
pubmed: 27649937
Nat Methods. 2008 Sep;5(9):763-75
pubmed: 18756197
Urology. 1998 Jul;52(1):143-51
pubmed: 9671889
Anal Bioanal Chem. 2009 May;394(1):47-59
pubmed: 19221721
J Urol. 2001 Oct;166(4):1549-54
pubmed: 11547129
Am J Physiol Regul Integr Comp Physiol. 2005 May;288(5):R1332-8
pubmed: 15650117
BJU Int. 2008 Nov;102(9):1162-7
pubmed: 18549429
BJU Int. 2009 Jan;103(2):248-53
pubmed: 18782310
Transplantation. 2003 Oct 15;76(7):1053-60
pubmed: 14557752
BJU Int. 2021 Apr;127(4):463-472
pubmed: 32940408
Neurourol Urodyn. 2017 Sep;36(7):1723-1733
pubmed: 27935100
J Urol. 2008 Jun;179(6):2103-10
pubmed: 18423691
Eur Urol. 2009 Apr;55(4):932-43
pubmed: 18755535
Int J Urol. 2012 Jul;19(7):676-82
pubmed: 22548443
J Urol. 2013 May;189(5):1967-74
pubmed: 23022012
Stem Cell Res Ther. 2018 Sep 21;9(1):239
pubmed: 30241573
Int Braz J Urol. 2012 Jan-Feb;38(1):17-24
pubmed: 22397778
World J Urol. 2000 Oct;18(5):324-9
pubmed: 11131309
J Urol. 2006 Dec;176(6 Pt 1):2729-35
pubmed: 17085204
Urology. 2013 Sep;82(3):743.e1-8
pubmed: 23866762
World J Urol. 2004 Oct;22(4):244-50
pubmed: 15365750
Am J Physiol Renal Physiol. 2009 Feb;296(2):F277-83
pubmed: 19091786
Tissue Eng Part A. 2011 Apr;17(7-8):1069-81
pubmed: 21091339
Neurourol Urodyn. 2020 Feb;39(2):594-602
pubmed: 31873953
J Urol. 2016 Dec;196(6):1809-1815
pubmed: 27267321
J Urol. 2008 Feb;179(2):775-8
pubmed: 18082194