Contributions of the international plant science community to the fight against infectious diseases in humans-part 2: Affordable drugs in edible plants for endemic and re-emerging diseases.
endemic disease
molecular farming
oral delivery
plant-made pharmaceuticals
re-emerging disease
Journal
Plant biotechnology journal
ISSN: 1467-7652
Titre abrégé: Plant Biotechnol J
Pays: England
ID NLM: 101201889
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
10
06
2021
received:
30
03
2021
accepted:
22
06
2021
pubmed:
29
6
2021
medline:
8
10
2021
entrez:
28
6
2021
Statut:
ppublish
Résumé
The fight against infectious diseases often focuses on epidemics and pandemics, which demand urgent resources and command attention from the health authorities and media. However, the vast majority of deaths caused by infectious diseases occur in endemic zones, particularly in developing countries, placing a disproportionate burden on underfunded health systems and often requiring international interventions. The provision of vaccines and other biologics is hampered not only by the high cost and limited scalability of traditional manufacturing platforms based on microbial and animal cells, but also by challenges caused by distribution and storage, particularly in regions without a complete cold chain. In this review article, we consider the potential of molecular farming to address the challenges of endemic and re-emerging diseases, focusing on edible plants for the development of oral drugs. Key recent developments in this field include successful clinical trials based on orally delivered dried leaves of Artemisia annua against malarial parasite strains resistant to artemisinin combination therapy, the ability to produce clinical-grade protein drugs in leaves to treat infectious diseases and the long-term storage of protein drugs in dried leaves at ambient temperatures. Recent FDA approval of the first orally delivered protein drug encapsulated in plant cells to treat peanut allergy has opened the door for the development of affordable oral drugs that can be manufactured and distributed in remote areas without cold storage infrastructure and that eliminate the need for expensive purification steps and sterile delivery by injection.
Identifiants
pubmed: 34181810
doi: 10.1111/pbi.13658
pmc: PMC8486237
mid: NIHMS1720196
doi:
Substances chimiques
Pharmaceutical Preparations
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1921-1936Subventions
Organisme : ORFDO NIH HHS
ID : HHSN268201600014C
Pays : United States
Organisme : Empresa Brasileira de Pesquisa Agropecuária
Organisme : NHLBI NIH HHS
ID : HHSN268201600011C
Pays : United States
Organisme : NASA
ID : NNX16AO69A
Pays : United States
Organisme : Austrian Science Fund FWF
ID : W 1224
Pays : Austria
Organisme : The NIH
ID : R01 GM 63879
Organisme : Ministerio de Ciencia e Innovación
ID : RTI2018-097613-B-I00
Organisme : European Research Council
ID : grant agreement 669982
Pays : International
Organisme : NIGMS NIH HHS
ID : R01 GM063879
Pays : United States
Organisme : Ministerio de Ciencia e Innovación
ID : AGL2017-85377-R
Organisme : Intramural NIH HHS
ID : ZIA BC011472
Pays : United States
Organisme : Novo Nordisk
Organisme : The NIH
ID : R01 133191
Organisme : Ministerio de Ciencia e Innovación
ID : PGC2018-097655-B-I00
Organisme : Generalitat de Catalunya
ID : Grups Consolidats2017-SGR828
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/J/00000166
Pays : United Kingdom
Organisme : Universidade Católica de Brasília (UCB), Brasília
Organisme : Shire/Takeda
Organisme : INCT BioSyn (National Institute of Science and Technology in Synthetic Biology)
Organisme : the John Innes Foundation and the Department of Health and Social Care using UK Aid funding managed by the BBSRC
Organisme : Fundação para a Ciência e a Tecnologia
ID : UIDB/04551/2020 (GREEN-IT - Bioresources for Susta
Organisme : European Research Council
ID : (ERC-ADG-2014
Pays : International
Organisme : The NIH
ID : R01 HL 109442
Organisme : EU Horizon 2020
ID : Pharma-Factory 774078
Organisme : CNPq, CAPES, Brazilian Ministry of Health, FAPDF
Organisme : Intramural NIH HHS
ID : ZIC BC010469
Pays : United States
Organisme : NASA Space Technology Research
ID : NNX17AJ31G
Organisme : Biotechnology and Biological Sciences Research Council
ID : Grant BB/L020955/1
Pays : United Kingdom
Organisme : FEDER
ID : Project LISBOA-01-0145-FEDER-007660
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/J/000PR9794
Pays : United Kingdom
Organisme : The NIH
ID : R01 107904
Organisme : Netherlands Organization for Scientific Research
ID : TTW Veni Grant 16740
Organisme : EU Horizon 2020
ID : 760331-2
Organisme : EU Horizon 2020
ID : Newcotiana
Organisme : UKIERI and the Hotung Foundation
Organisme : Austrian Science Fund FWF
ID : project W1224
Pays : Austria
Organisme : CRAFT award (COVID-19) by the University of California Davis
Organisme : The Max Planck Society
Organisme : Bayer
Organisme : NHLBI NIH HHS
ID : R01 HL109442
Pays : United States
Informations de copyright
© 2021 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.
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