A review of the mechanisms underlying selected comorbidities in Alzheimer's disease.
Alzheimer's disease
Comorbidities
Depression
Diabetes mellitus
Down syndrome
Hypercholesterolemia
Journal
Pharmacological reports : PR
ISSN: 2299-5684
Titre abrégé: Pharmacol Rep
Pays: Switzerland
ID NLM: 101234999
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
16
03
2021
accepted:
31
05
2021
revised:
27
05
2021
pubmed:
15
6
2021
medline:
9
2
2022
entrez:
14
6
2021
Statut:
ppublish
Résumé
Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the central nervous system (CNS) leading to mental deterioration and devastation, and eventually a fatal outcome. AD affects mostly the elderly. AD is frequently accompanied by hypercholesterolemia, hypertension, atherosclerosis, and diabetes mellitus, and these are significant risk factors of AD. Other conditions triggered by the progression of AD include psychosis, sleep disorders, epilepsy, and depression. One important comorbidity is Down's syndrome, which directly contributes to the severity and rapid progression of AD. The development of new therapeutic strategies for AD includes the repurposing of drugs currently used for the treatment of comorbidities. A better understanding of the influence of comorbidities on the pathogenesis of AD, and the medications used in its treatment, might allow better control of disease progression, and more effective pharmacotherapy.
Identifiants
pubmed: 34121170
doi: 10.1007/s43440-021-00293-5
pii: 10.1007/s43440-021-00293-5
pmc: PMC8599320
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1565-1581Subventions
Organisme : Narodowym Centrum Nauki
ID : 2015/19/B/NZ7/02847
Informations de copyright
© 2021. The Author(s).
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