Enhancer release and retargeting activates disease-susceptibility genes.

CCCTC-Binding Factor / genetics CRISPR-Cas Systems Cell Cycle Proteins / genetics Cells, Cultured Chromatin Chromosomal Proteins, Non-Histone / genetics Enhancer Elements, Genetic Gene Deletion Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease Genome-Wide Association Study Humans MCF-7 Cells Neoplasms / genetics Neural Stem Cells Oncogenes Parkinson Disease / genetics Promoter Regions, Genetic Cohesins

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
07 2021
Historique:
received: 14 06 2018
accepted: 23 04 2021
pubmed: 28 5 2021
medline: 27 1 2022
entrez: 27 5 2021
Statut: ppublish

Résumé

The functional engagement between an enhancer and its target promoter ensures precise gene transcription

Identifiants

DOI: 10.1038/s41586-021-03577-1 PMID: 34040254
pubmed: 34040254
doi: 10.1038/s41586-021-03577-1
pii: 10.1038/s41586-021-03577-1
doi:

Substances chimiques

CCCTC-Binding Factor 0
Cell Cycle Proteins 0
Chromatin 0
Chromosomal Proteins, Non-Histone 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

735-740

Subventions

Organisme : NIGMS NIH HHS
ID : R21 GM132778
Pays : United States
Organisme : NIDDK NIH HHS
ID : R37 DK039949
Pays : United States
Organisme : NICHD NIH HHS
ID : F32 HD008118
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL150521
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA184770
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS093066
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL156059
Pays : United States
Organisme : NCI NIH HHS
ID : K22 CA204468
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG008153
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM136922
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK018477
Pays : United States

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Soohwan Oh (S)

Howard Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, CA, USA.

Jiaofang Shao (J)

Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
ORCID: 0000-0003-0177-4844

Joydeep Mitra (J)

Department of Genetics, Albert Einstein College of Medicine, New York, NY, USA.
ORCID: 0000-0001-5806-7329

Feng Xiong (F)

Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.

Matteo D'Antonio (M)

Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA.
ORCID: 0000-0001-5844-6433

Ruoyu Wang (R)

Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Graduate School of Biomedical Sciences, University of Texas MD Anderson Cancer Center and UTHealth, Houston, TX, USA.
ORCID: 0000-0002-3644-1284

Ivan Garcia-Bassets (I)

Department of Medicine, School of Medicine, University of California San Diego, La Jolla, CA, USA.
ORCID: 0000-0002-6941-9585

Qi Ma (Q)

Howard Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, CA, USA.
ORCID: 0000-0002-8705-4460

Xiaoyu Zhu (X)

Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.

Joo-Hyung Lee (JH)

Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.

Sreejith J Nair (SJ)

Howard Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, CA, USA.

Feng Yang (F)

Howard Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, CA, USA.

Kenneth Ohgi (K)

Howard Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, CA, USA.

Kelly A Frazer (KA)

Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA.

Zhengdong D Zhang (ZD)

Department of Genetics, Albert Einstein College of Medicine, New York, NY, USA.

Wenbo Li (W)

Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA. Wenbo.li@uth.tmc.edu.
Graduate School of Biomedical Sciences, University of Texas MD Anderson Cancer Center and UTHealth, Houston, TX, USA. Wenbo.li@uth.tmc.edu.
ORCID: 0000-0002-9042-5664

Michael G Rosenfeld (MG)

Howard Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, CA, USA. mrosenfeld@health.ucsd.edu.
ORCID: 0000-0002-1572-156X

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Classifications MeSH

Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Facteur de liaison à la séquence CCCTC › Enhancer release and retargeting activates...
Recherchemedicale.com › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Systèmes CRISPR-Cas › Enhancer release and retargeting activates...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › Enhancer release and retargeting activates...
Recherchemedicale.com › Cellules › Cellules cultivées › Enhancer release and retargeting activates...
Recherchemedicale.com › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Enhancer release and retargeting activates...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines chromosomiques nonhistones › Enhancer release and retargeting activates...
Recherchemedicale.com › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Éléments activateurs (génétique) › Enhancer release and retargeting activates...
Recherchemedicale.com › Phénomènes génétiques › Mutagenèse › Délétion de séquence › Délétion de gène › Enhancer release and retargeting activates...
Recherchemedicale.com › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Enhancer release and retargeting activates...
Recherchemedicale.com › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Enhancer release and retargeting activates...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Enhancer release and retargeting activates...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Enhancer release and retargeting activates...
Recherchemedicale.com › Cellules › Cellules cultivées › Lignée cellulaire › Cellules MCF-7 › Enhancer release and retargeting activates...
Recherchemedicale.com › Tumeurs › Enhancer release and retargeting activates...
Recherchemedicale.com › Cellules › Cellules souches › Cellules souches neurales › Enhancer release and retargeting activates...
Recherchemedicale.com › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes tumoraux › Oncogènes › Enhancer release and retargeting activates...
Recherchemedicale.com › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Enhancer release and retargeting activates...
Recherchemedicale.com › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › Enhancer release and retargeting activates...