Angiogenic factors and prediction for ischemic placental disease in future pregnancies.
Abruption
Angiogenic factors
Ischemic placental disease
Preeclampsia
Small for gestational age
Journal
Pregnancy hypertension
ISSN: 2210-7797
Titre abrégé: Pregnancy Hypertens
Pays: Netherlands
ID NLM: 101552483
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
17
08
2020
accepted:
08
05
2021
pubmed:
22
5
2021
medline:
15
12
2021
entrez:
21
5
2021
Statut:
ppublish
Résumé
Ischemic placental disease (IPD), including preeclampsia, abruption, and fetal growth restriction, often recurs in subsequent pregnancies. Angiogenic factors of placental origin have been implicated in the pathogenesis of preeclampsia, but have not been studied as predictors of IPD in subsequent pregnancies. We hypothesized that elevated angiogenic factors in an index pregnancy would be associated with recurrence of IPD. We conducted a retrospective cohort study of patients undergoing evaluation for preeclampsia who had angiogenic factors measured in an index pregnancy and experienced a subsequent pregnancy at the same institution. Patients with IPD in the index pregnancy were included. A high ratio of soluble fms-like tyrosine kinase 1 (sFlt1) and placental growth factor (PlGF) was defined as greater than or equal to 85. The primary outcome was IPD in a subsequent pregnancy. We included 109 patients in the analysis. The sFlt1/PlGF ratio was elevated in 30% of participants. Those with an elevated ratio were more likely to be nulliparous in the index pregnancy, and less likely to have chronic hypertension. The recurrence of IPD in the study was 27%, with a non-significant difference in risk based on a high sFlt-1/P1GF ratio RR 0.58 (95% CI 0.21 - 1.6) compared to a low ratio. A high sFlt1/P1GF ratio in an index pregnancy is not associated with a higher risk of IPD in a subsequent pregnancy. These data suggest placental angiogenic biomarkers are specific to the pregnancy and not a reflection of maternal predisposition to IPD.
Identifiants
pubmed: 34020330
pii: S2210-7789(21)00040-4
doi: 10.1016/j.preghy.2021.05.011
pmc: PMC8363546
mid: NIHMS1708661
pii:
doi:
Substances chimiques
Angiogenesis Inducing Agents
0
PGF protein, human
0
Placenta Growth Factor
144589-93-5
FLT1 protein, human
EC 2.7.10.1
Vascular Endothelial Growth Factor Receptor-1
EC 2.7.10.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
12-17Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR002541
Pays : United States
Informations de copyright
Copyright © 2021 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.
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