Cinacalcet may suppress kidney enlargement in hemodialysis patients with autosomal dominant polycystic kidney disease.
Aged
Calcium
/ blood
Calcium-Regulating Hormones and Agents
/ pharmacology
Cinacalcet
/ pharmacology
Female
Humans
Hypertrophy
/ etiology
Kidney
/ drug effects
Kidney Failure, Chronic
/ blood
Male
Middle Aged
Organ Size
/ drug effects
Parathyroid Hormone
/ blood
Phosphates
/ blood
Polycystic Kidney, Autosomal Dominant
/ blood
Retrospective Studies
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 05 2021
11 05 2021
Historique:
received:
07
11
2020
accepted:
21
04
2021
entrez:
12
5
2021
pubmed:
13
5
2021
medline:
5
11
2021
Statut:
epublish
Résumé
A massively enlarged kidney can impact quality of life of autosomal dominant polycystic kidney disease (ADPKD) patients. A recent in vitro study demonstrated that an allosteric modulator of the calcium sensing receptor decreases adenosine-3',5'-cyclic monophosphate, an important factor for kidney enlargement in ADPKD. Therefore, the present study was performed to determine whether cinacalcet, a calcium sensing receptor agonist, suppresses kidney enlargement in hemodialysis patients with ADPKD. Alteration of total kidney volume together with clinical parameters was retrospectively examined in 12 hemodialysis patients with ADPKD treated at a single institution in Japan. In the non-cinacalcet group with longer hemodialysis duration (n = 5), total kidney volume had an annual increase of 4.19 ± 1.71% during an overall period of 877 ± 494 days. In contrast, the annual rate of increase in total kidney volume in the cinacalcet group (n = 7) was significantly suppressed after cinacalcet treatment, from 3.26 ± 2.87% during a period of 734 ± 352 days before the start of cinacalcet to - 4.71 ± 6.42% during 918 ± 524 days after initiation of treatment (p = 0.047). The present findings showed that cinacalcet could be a novel therapeutic tool for suppression of kidney enlargement in hemodialysis patients with ADPKD.
Identifiants
pubmed: 33976330
doi: 10.1038/s41598-021-89480-1
pii: 10.1038/s41598-021-89480-1
pmc: PMC8113347
doi:
Substances chimiques
Calcium-Regulating Hormones and Agents
0
Parathyroid Hormone
0
Phosphates
0
Calcium
SY7Q814VUP
Cinacalcet
UAZ6V7728S
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
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