On-admission anemia predicts mortality in COVID-19 patients: A single center, retrospective cohort study.
Acute Kidney Injury
/ epidemiology
Aged
Aged, 80 and over
Anemia
/ blood
Blood Transfusion
/ statistics & numerical data
COVID-19
/ blood
Cause of Death
Cohort Studies
Female
Hemoglobins
/ metabolism
Hospital Mortality
Hospitalization
Humans
Hypotension
/ epidemiology
Intensive Care Units
Male
Middle Aged
Respiration, Artificial
/ statistics & numerical data
Respiratory Insufficiency
/ epidemiology
Retrospective Studies
SARS-CoV-2
Severity of Illness Index
Shock, Septic
/ epidemiology
Anemia
COVID-19
Emergency department
Hypoxic respiratory failure
Mortality
Sepsis
Journal
The American journal of emergency medicine
ISSN: 1532-8171
Titre abrégé: Am J Emerg Med
Pays: United States
ID NLM: 8309942
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
12
12
2020
revised:
19
03
2021
accepted:
27
03
2021
pubmed:
26
4
2021
medline:
14
7
2022
entrez:
25
4
2021
Statut:
ppublish
Résumé
We investigated the impact of anemia based on admission hemoglobin (Hb) level as a prognostic risk factor for severe outcomes in hospitalized patients with coronavirus disease 2019 (COVID-19). A single-center, retrospective cohort study was conducted from a random sample of 733 adult patients (age ≥ 18 years) obtained from a total of 4356 laboratory confirmed SARS-CoV-2 cases who presented to the Emergency Department of Montefiore Medical Center between March-June 2020. The primary outcome was a composite endpoint of in-hospital severe outcomes of COVID-19. A secondary outcome was in-hospital all-cause mortality. Among the 733 patients included in our final analysis, 438 patients (59.8%) presented with anemia. 105 patients (14.3%) had mild, and 333 patients (45.5%) had moderate-severe anemia. Overall, 437 patients (59.6%) had a composite endpoint of severe outcomes. On-admission anemia was an independent risk factor for all-cause mortality, (Odds Ratio 1.52, 95% CI [1.01-2.30], p = 0.046) but not for composite severe outcomes. However, moderate-severe anemia (Hb < 11 g/dL) on admission was independently associated with both severe outcomes (OR1.53, 95% CI [1.05-2.23], p = 0.028) and mortality (OR 1.67, 95% CI [1.09-2.56], p = 0.019) during hospitalization. Anemia on admission was independently associated with increased odds of all-cause mortality in patients hospitalized with COVID-19. Furthermore, moderate-severe anemia (Hb <11 g/dL) was an independent risk factor for severe COVID-19 outcomes. Moving forward, COVID-19 patient management and risk stratification may benefit from addressing anemia on admission.
Identifiants
pubmed: 33895645
pii: S0735-6757(21)00270-9
doi: 10.1016/j.ajem.2021.03.083
pmc: PMC8007204
pii:
doi:
Substances chimiques
Hemoglobins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
140-147Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR002556
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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