Involvement of mitochondrial fission in renal tubular pyroptosis in mice exposed to high and environmental levels of glyphosate combined with hard water.
Chronic interstitial nephritis in agricultural communities (CINAC)
Glyphosate
Hard water
Mitochondrial fission
Pyroptosis
Journal
Environmental pollution (Barking, Essex : 1987)
ISSN: 1873-6424
Titre abrégé: Environ Pollut
Pays: England
ID NLM: 8804476
Informations de publication
Date de publication:
15 Aug 2021
15 Aug 2021
Historique:
received:
07
12
2020
revised:
20
03
2021
accepted:
01
04
2021
pubmed:
14
4
2021
medline:
16
6
2021
entrez:
13
4
2021
Statut:
ppublish
Résumé
Chronic interstitial nephritis in agricultural communities (CINAC) has reached epidemic proportions. The combination of glyphosate and hard water has been postulated to play a potent aetiological role in CINAC. Therefore, dynamin-related protein 1 (Drp1)-mediated aberrant mitochondrial fission and subsequent activation of the nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (Nlrp3)/caspase1 pathway may be involved in the pathogenesis of nephropathy. In the present study, mice were sub-chronically exposed to high doses and environmental levels of glyphosate (100 mg/kg body weight (mg/kg·bw) glyphosate in Roundup and 0.7 mg/L pure glyphosate, respectively) and hard water (2500 mg/L CaCO3 and 250 mg/L Ca
Identifiants
pubmed: 33848899
pii: S0269-7491(21)00664-3
doi: 10.1016/j.envpol.2021.117082
pii:
doi:
Substances chimiques
Water
059QF0KO0R
Glycine
TE7660XO1C
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
117082Informations de copyright
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