Drifts in Prefrontal and Parietal Neuronal Activity Influence Working Memory Judgments.
Animals
Electrophysiological Phenomena
Judgment
/ physiology
Macaca mulatta
Magnetic Resonance Imaging
Male
Memory, Short-Term
/ physiology
Mental Recall
Neurons
/ physiology
Parietal Lobe
/ physiology
Photic Stimulation
Prefrontal Cortex
/ physiology
Psychomotor Performance
Reaction Time
/ physiology
monkey
neurophysiology
parietal cortex
prefrontal cortex
working memory
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
05 07 2021
05 07 2021
Historique:
received:
04
08
2020
revised:
29
12
2020
accepted:
26
01
2021
pubmed:
7
4
2021
medline:
8
3
2022
entrez:
6
4
2021
Statut:
ppublish
Résumé
The dorsolateral prefrontal cortex (dlPFC) plays a critical role in spatial working memory and its activity predicts behavioral responses in delayed response tasks. Here, we addressed if this predictive ability extends to other working memory tasks and if it is present in other brain areas. We trained monkeys to remember the location of a stimulus and determine whether a second stimulus appeared at the same location or not. Neurophysiological recordings were performed in the dorsolateral prefrontal cortex and posterior parietal cortex (PPC). We hypothesized that random drifts causing the peak activity of the network to move away from the first stimulus location and toward the location of the second stimulus would result in categorical errors. Indeed, for both areas, in nonmatching trials, when the first stimulus appeared in a neuron's preferred location, the neuron showed significantly higher firing rates in correct than in error trials; and vice versa, when the first stimulus appeared at a nonpreferred location, activity in error trials was higher than in correct. The results indicate that the activity of both dlPFC and PPC neurons is predictive of categorical judgments of information maintained in working memory, and neuronal firing rate deviations are revealing of the contents of working memory.
Identifiants
pubmed: 33822919
pii: 6209410
doi: 10.1093/cercor/bhab038
pmc: PMC8258436
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3650-3664Subventions
Organisme : NEI NIH HHS
ID : R01 EY016773
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY017077
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH116675
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.
Références
Behav Brain Res. 2013 Mar 15;241:235-43
pubmed: 23261872
Science. 2001 Jan 12;291(5502):312-6
pubmed: 11209083
Trends Cogn Sci. 2014 Feb;18(2):82-9
pubmed: 24439529
Cereb Cortex. 2014 Sep;24(9):2334-49
pubmed: 23547137
Cereb Cortex. 2000 Sep;10(9):910-23
pubmed: 10982751
Vis Neurosci. 1996 Jan-Feb;13(1):87-100
pubmed: 8730992
Elife. 2020 May 07;9:
pubmed: 32379044
Eur J Neurosci. 2014 Sep;40(6):2910-21
pubmed: 24964224
Front Neural Circuits. 2020 May 07;14:15
pubmed: 32528254
J Neurophysiol. 1998 Jun;79(6):2919-40
pubmed: 9636098
J Neurosci Methods. 2005 Mar 15;142(1):27-34
pubmed: 15652614
Cell Rep. 2016 Mar 29;14(12):2765-73
pubmed: 26997283
Front Syst Neurosci. 2010 May 14;4:12
pubmed: 20514341
J Neurosci. 2013 Jun 19;33(25):10301-11
pubmed: 23785144
Science. 1986 Sep 26;233(4771):1416-9
pubmed: 3749885
J Neurosci. 2018 Aug 8;38(32):7020-7028
pubmed: 30089641
J Neurophysiol. 2000 Jul;84(1):401-14
pubmed: 10899214
J Neurophysiol. 1971 May;34(3):337-47
pubmed: 4997822
J Neurophysiol. 2012 Jul;108(1):31-8
pubmed: 22490554
Front Integr Neurosci. 2013 May 09;7:35
pubmed: 23675328
Nat Neurosci. 2001 Mar;4(3):311-6
pubmed: 11224549
Neurobiol Learn Mem. 2009 Feb;91(2):129-38
pubmed: 19116173
Nat Neurosci. 2013 Oct;16(10):1484-91
pubmed: 23995071
J Neurosci. 2017 Jun 21;37(25):6098-6112
pubmed: 28539423
Trends Neurosci. 2001 Aug;24(8):455-63
pubmed: 11476885
Nat Neurosci. 2002 Feb;5(2):175-80
pubmed: 11802172
Trends Cogn Sci. 2017 Feb;21(2):111-124
pubmed: 28063661
Nat Neurosci. 2020 Aug;23(8):1016-1024
pubmed: 32572236
Nat Neurosci. 2014 Sep;17(9):1255-62
pubmed: 25108910
Trends Neurosci. 2019 Sep;42(9):604-616
pubmed: 31443912
J Cogn Neurosci. 2013 May;25(5):754-61
pubmed: 23469889
Curr Biol. 2013 Aug 5;23(15):1427-31
pubmed: 23871239
Front Syst Neurosci. 2016 Jan 05;9:181
pubmed: 26778980
Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1368-73
pubmed: 14742867
Nat Rev Neurosci. 2016 Jul;17(7):438-49
pubmed: 27225070
Cogn Affect Behav Neurosci. 2005 Jun;5(2):144-55
pubmed: 16180621
Nat Neurosci. 2016 Mar;19(3):394-403
pubmed: 26906506
Neuron. 2017 Jan 18;93(2):323-330
pubmed: 28041884
Nat Neurosci. 2014 Mar;17(3):431-9
pubmed: 24487232
Cereb Cortex. 2018 Nov 1;28(11):3816-3828
pubmed: 29040434
J Cogn Neurosci. 2014 May;26(5):1141-53
pubmed: 24392897
Nature. 2004 Apr 15;428(6984):751-4
pubmed: 15085133
J Neurophysiol. 1996 Aug;76(2):1352-5
pubmed: 8871242
Neuron. 2014 Jul 2;83(1):226-37
pubmed: 24991963
Annu Rev Psychol. 2012;63:1-29
pubmed: 21961947
Exp Brain Res. 1988;70(1):216-20
pubmed: 3402565
Neuron. 2018 Oct 24;100(2):463-475
pubmed: 30359609
Nat Commun. 2016 Nov 09;7:13423
pubmed: 27827365
Nat Neurosci. 2012 Jan 15;15(2):315-20
pubmed: 22246435
J Neurosci. 2013 May 8;33(19):8359-69
pubmed: 23658175
Science. 1971 Aug 13;173(3997):652-4
pubmed: 4998337
J Neurophysiol. 1989 Feb;61(2):331-49
pubmed: 2918358
J Neurosci. 2018 Aug 8;38(32):7013-7019
pubmed: 30089640
Nat Neurosci. 2013 Jan;16(1):98-104
pubmed: 23242309
J Neurophysiol. 2013 Dec;110(11):2648-60
pubmed: 24047904
Somatosens Mot Res. 1993;10(3):245-62
pubmed: 8237213
J Neurophysiol. 2015 Oct;114(4):2194-203
pubmed: 26269556
Neuron. 2016 Apr 6;90(1):152-164
pubmed: 26996084
Annu Rev Neurosci. 2017 Jul 25;40:603-627
pubmed: 28772102
Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):394-399
pubmed: 28028221
Cogn Affect Behav Neurosci. 2004 Dec;4(4):444-65
pubmed: 15849890
J Neurosci. 2016 Apr 6;36(14):4067-79
pubmed: 27053213
Trends Cogn Sci. 2015 Jul;19(7):394-405
pubmed: 26051384
J Comp Neurol. 1989 Sep 22;287(4):393-421
pubmed: 2477405
Nature. 2009 Apr 2;458(7238):632-5
pubmed: 19225460
PLoS One. 2012;7(7):e41053
pubmed: 22848426
J Neurophysiol. 2015 Jan 1;113(1):44-57
pubmed: 25298389