Succinate Mediates Tumorigenic Effects

Animals Humans Mice Mutation Paraganglioma / drug therapy Pheochromocytoma / drug therapy Protein Subunits / genetics Rats Receptors, G-Protein-Coupled / antagonists & inhibitors Succinate Dehydrogenase / deficiency Succinic Acid / metabolism
SDHB gene SUCNR1 (GPR91) paraganglioma succinate succinate receptor 1

Journal

Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782

Informations de publication

Date de publication:
2021
Historique:
received: 30 07 2020
accepted: 29 01 2021
entrez: 29 3 2021
pubmed: 30 3 2021
medline: 19 1 2022
Statut: epublish

Résumé

Paragangliomas and pheochromocytomas (PPGLs) are chromaffin tumors associated with severe catecholamine-induced morbidities. Surgical removal is often curative. However, complete resection may not be an option for patients with succinate dehydrogenase subunit A-D (

Identifiants

DOI: 10.3389/fendo.2021.589451 PMID: 33776908 PMC: PMC7994772
pubmed: 33776908
doi: 10.3389/fendo.2021.589451
pmc: PMC7994772
doi:

Substances chimiques

Protein Subunits 0
Receptors, G-Protein-Coupled 0
SDHD protein, human 0
SUCNR1 protein, human 0
Succinic Acid AB6MNQ6J6L
Succinate Dehydrogenase EC 1.3.99.1

Types de publication

Journal Article Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

589451

Informations de copyright

Copyright © 2021 Matlac, Hadrava Vanova, Bechmann, Richter, Folberth, Ghayee, Ge, Abunimer, Wesley, Aherrahrou, Dona, Martínez-Montes, Calsina, Merino, Schwaninger, Deen, Zhuang, Neuzil, Pacak, Lehnert and Fliedner.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Dieter M Matlac (DM)

Neuroendocrine Oncology and Metabolism, Medical Department I, Center of Brain, Behavior, and Metabolism, University Medical Center Schleswig-Holstein Lübeck, Lübeck, Germany.

Katerina Hadrava Vanova (K)

Institute of Biotechnology, Czech Academy of Sciences, Prague-West, Czechia.
Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.

Nicole Bechmann (N)

Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Susan Richter (S)

Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Julica Folberth (J)

Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.

Hans K Ghayee (HK)

Department of Medicine, Division of Endocrinology, University of Florida and Malcom Randall VA Medical Center, Gainesville, FL, United States.

Guang-Bo Ge (GB)

Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Luma Abunimer (L)

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.

Robert Wesley (R)

Neuroendocrine Oncology and Metabolism, Medical Department I, Center of Brain, Behavior, and Metabolism, University Medical Center Schleswig-Holstein Lübeck, Lübeck, Germany.
Institute of Biotechnology, Czech Academy of Sciences, Prague-West, Czechia.
Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.
Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.
Department of Medicine, Division of Endocrinology, University of Florida and Malcom Randall VA Medical Center, Gainesville, FL, United States.
Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany.
Department of Biomedical Engineering, Centre for Public Health Genomics, University of Virginia, Charlottesville, VA, United States.
Division of Endocrinology 471, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands.
Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Laboratory of Surgical Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Radboud University, Nijmegen, Netherlands.
Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.
School of Medical Science, Griffith University, Southport, QLD, Australia.

Redouane Aherrahrou (R)

Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany.
Department of Biomedical Engineering, Centre for Public Health Genomics, University of Virginia, Charlottesville, VA, United States.

Margo Dona (M)

Division of Endocrinology 471, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands.

Ángel M Martínez-Montes (ÁM)

Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

Bruna Calsina (B)

Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

Maria J Merino (MJ)

Laboratory of Surgical Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

Markus Schwaninger (M)

Institute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.

Peter M T Deen (PMT)

Radboud University, Nijmegen, Netherlands.

Zhengping Zhuang (Z)

Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.

Jiri Neuzil (J)

Institute of Biotechnology, Czech Academy of Sciences, Prague-West, Czechia.
School of Medical Science, Griffith University, Southport, QLD, Australia.

Karel Pacak (K)

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.

Hendrik Lehnert (H)

Neuroendocrine Oncology and Metabolism, Medical Department I, Center of Brain, Behavior, and Metabolism, University Medical Center Schleswig-Holstein Lübeck, Lübeck, Germany.

Stephanie M J Fliedner (SMJ)

Neuroendocrine Oncology and Metabolism, Medical Department I, Center of Brain, Behavior, and Metabolism, University Medical Center Schleswig-Holstein Lübeck, Lübeck, Germany.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Succinate Mediates Tumorigenic Effects
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Succinate Mediates Tumorigenic Effects
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Succinate Mediates Tumorigenic Effects
Recherchemedicale.com › Phénomènes génétiques › Variation génétique › Mutation › Succinate Mediates Tumorigenic Effects
Recherchemedicale.com › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroendocrines › Paragangliome › Succinate Mediates Tumorigenic Effects
Recherchemedicale.com › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroendocrines › Paragangliome › Phéochromocytome › Succinate Mediates Tumorigenic Effects
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Sous-unités de protéines › Succinate Mediates Tumorigenic Effects
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Succinate Mediates Tumorigenic Effects
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Succinate Mediates Tumorigenic Effects
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Protéines à fer non hème › Ferrosulfoprotéines › Complexe II de la chaîne respiratoire › Succinate Dehydrogenase › Succinate Mediates Tumorigenic Effects
Recherchemedicale.com › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Diacides carboxyliques › Succinates › Acide succinique › Succinate Mediates Tumorigenic Effects