Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer.

Animals Antineoplastic Agents / pharmacology Biomarkers, Tumor / genetics Cell Line, Tumor Cell Lineage Drug Resistance, Neoplasm Gene Expression Profiling Gene Expression Regulation, Neoplastic Genes, MHC Class I Humans Immunophenotyping Lung Neoplasms / drug therapy Mice Neuroendocrine Tumors / drug therapy Phenotype Small Cell Lung Carcinoma / drug therapy Transcriptome Tumor Microenvironment Xenograft Model Antitumor Assays

Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
09 03 2021
Historique:
received: 07 12 2020
accepted: 09 02 2021
entrez: 22 3 2021
pubmed: 23 3 2021
medline: 10 8 2021
Statut: epublish

Résumé

Small cell lung cancer (SCLC) is classified as a high-grade neuroendocrine (NE) tumor, but a subset of SCLC has been termed "variant" due to the loss of NE characteristics. In this study, we computed NE scores for patient-derived SCLC cell lines and xenografts, as well as human tumors. We aligned NE properties with transcription factor-defined molecular subtypes. Then we investigated the different immune phenotypes associated with high and low NE scores. We found repression of immune response genes as a shared feature between classic SCLC and pulmonary neuroendocrine cells of the healthy lung. With loss of NE fate, variant SCLC tumors regain cell-autonomous immune gene expression and exhibit higher tumor-immune interactions. Pan-cancer analysis revealed this NE lineage-specific immune phenotype in other cancers. Additionally, we observed MHC I re-expression in SCLC upon development of chemoresistance. These findings may help guide the design of treatment regimens in SCLC.

Identifiants

DOI: 10.1038/s42003-021-01842-7 PMID: 33750914 PMC: PMC7943563
pubmed: 33750914
doi: 10.1038/s42003-021-01842-7
pii: 10.1038/s42003-021-01842-7
pmc: PMC7943563
doi:

Substances chimiques

Antineoplastic Agents 0
Biomarkers, Tumor 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

314

Subventions

Organisme : NCI NIH HHS
ID : R35 CA220449
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA142543
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM115473
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA070907
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM136375
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA213338
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA220449
Pays : United States

Références

Nat Biotechnol. 2017 Apr 11;35(4):314-316
pubmed: 28398314
Nat Rev Cancer. 2019 May;19(5):289-297
pubmed: 30926931
Nucleic Acids Res. 2016 Jul 8;44(W1):W90-7
pubmed: 27141961
J Thorac Oncol. 2015 Sep;10(9):1243-1260
pubmed: 26291008
Nat Rev Cancer. 2017 Nov 10;17(12):765
pubmed: 29123245
Nature. 2019 May;569(7757):503-508
pubmed: 31068700
Cancer Sci. 2016 Dec;107(12):1755-1766
pubmed: 27627196
Nature. 2020 Nov;587(7835):619-625
pubmed: 33208946
Genes Dev. 2015 Jul 15;29(14):1447-62
pubmed: 26220992
J Biol Chem. 1999 Oct 22;274(43):30353-6
pubmed: 10521409
Cancer Cell. 2019 Oct 14;36(4):385-401.e8
pubmed: 31564637
Nat Microbiol. 2020 Nov;5(11):1330-1339
pubmed: 32704094
J Clin Invest. 2017 Aug 1;127(8):2930-2940
pubmed: 28650338
Genome Biol. 2016 Jul 08;17(1):145
pubmed: 27386949
Br J Pharmacol. 2008 Sep;155(2):152-69
pubmed: 18641677
Nucleic Acids Res. 2013 Jan;41(Database issue):D1228-33
pubmed: 23180781
Immun Inflamm Dis. 2017 Sep;5(3):218-232
pubmed: 28474781
Nat Med. 2018 Aug;24(8):1143-1150
pubmed: 30038220
PLoS Genet. 2016 Apr 19;12(4):e1005895
pubmed: 27093186
J Cell Biochem Suppl. 1996;24:210-7
pubmed: 8806103
Science. 2011 Jan 7;331(6013):44-9
pubmed: 21212348
Cancer Discov. 2018 Oct;8(10):1316-1331
pubmed: 30228179
Science. 2018 Dec 21;362(6421):1416-1422
pubmed: 30573629
Nat Biotechnol. 2010 May;28(5):511-5
pubmed: 20436464
BMC Bioinformatics. 2010 Feb 18;11:94
pubmed: 20167110
Cell. 2018 May 3;173(4):864-878.e29
pubmed: 29681454
Oncogene. 2019 Apr;38(14):2551-2564
pubmed: 30532070
Nature. 1997 Apr 24;386(6627):852-5
pubmed: 9126746
Nat Genet. 2012 Oct;44(10):1111-6
pubmed: 22941189
BMC Bioinformatics. 2009 Feb 03;10:48
pubmed: 19192299
J Clin Invest. 2021 Jan 4;131(1):
pubmed: 33079728
J Thorac Oncol. 2012 Dec;7(12):1747-1754
pubmed: 23154545
Database (Oxford). 2017 Jan 1;2017:
pubmed: 31725860
Sci Rep. 2018 Jan 31;8(1):1922
pubmed: 29386574
Cancer Discov. 2018 Sep;8(9):1142-1155
pubmed: 29884728
Nat Genet. 2013 Mar;45(3):279-84
pubmed: 23334666
Bioinformatics. 2004 Feb 12;20(3):307-15
pubmed: 14960456
Sci Transl Med. 2013 May 22;5(186):186ra66
pubmed: 23698379
Nucleic Acids Res. 2005 Nov 10;33(20):e175
pubmed: 16284200
Am J Respir Crit Care Med. 1996 Sep;154(3 Pt 1):758-63
pubmed: 8810616
Cancer Cell. 2011 Jun 14;19(6):754-64
pubmed: 21665149
Transl Lung Cancer Res. 2018 Feb;7(1):32-49
pubmed: 29535911
Clin Cancer Res. 2016 Dec 15;22(24):6278-6289
pubmed: 27252415
Nucleic Acids Res. 2013 Jan;41(Database issue):D1040-6
pubmed: 23203888
Cancer Res. 1985 Jun;45(6):2924-30
pubmed: 2985258
Nat Biotechnol. 2019 Dec;37(12):1482-1492
pubmed: 31796933
PLoS Biol. 2008 Dec 2;6(12):2853-68
pubmed: 19053174
Biochimie. 2017 Nov;142:1-10
pubmed: 28778717
Front Immunol. 2018 Apr 18;9:813
pubmed: 29720980
Genes Dev. 2018 Jul 1;32(13-14):915-928
pubmed: 29945888
Genes Dev. 2011 Oct 15;25(20):2125-36
pubmed: 21979375
Cell Cycle. 2011 Aug 15;10(16):2806-15
pubmed: 21822053
ILAR J. 2017 Jul 1;58(1):17-41
pubmed: 28838066
PLoS One. 2011;6(7):e21800
pubmed: 21789182
Bioinformatics. 2016 Sep 15;32(18):2847-9
pubmed: 27207943
Cell Syst. 2015 Dec 23;1(6):417-425
pubmed: 26771021
J Thorac Oncol. 2015 Apr;10(4):553-64
pubmed: 25675280
Nature. 2010 Jan 14;463(7278):184-90
pubmed: 20016488
Nat Rev Clin Oncol. 2020 May;17(5):300-312
pubmed: 32055013
Nat Rev Cancer. 2017 Dec;17(12):725-737
pubmed: 29077690
J Exp Med. 1985 May 1;161(5):1135-51
pubmed: 2580935
Immunity. 2018 Apr 17;48(4):812-830.e14
pubmed: 29628290
Nature. 2009 Nov 5;462(7269):108-12
pubmed: 19847166
Cancer Immunol Res. 2015 Apr;3(4):412-23
pubmed: 25691328
Clin Cancer Res. 2014 Feb 15;20(4):938-50
pubmed: 24284055
J Virol. 2012 Mar;86(5):2437-46
pubmed: 22190720
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Nature. 2017 May 18;545(7654):360-364
pubmed: 28489825
Bioinformatics. 2007 Jul 15;23(14):1846-7
pubmed: 17496320
N Engl J Med. 2017 Dec 21;377(25):2500-2501
pubmed: 29262275
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Eur Cytokine Netw. 2000 Sep;11(3):483-6
pubmed: 11203186
Annu Rev Virol. 2019 Sep 29;6(1):567-584
pubmed: 31283436
Trends Immunol. 2010 Jun;31(6):220-7
pubmed: 20538542
Nature. 2015 Aug 6;524(7563):47-53
pubmed: 26168399
Cancers (Basel). 2011 Oct 13;3(4):3856-93
pubmed: 24213115
Cancer Discov. 2018 May;8(5):600-615
pubmed: 29483136
PLoS One. 2015 Dec 30;10(12):e0146021
pubmed: 26717316
BMC Bioinformatics. 2013 Jan 16;14:7
pubmed: 23323831
Cancer Cell. 2020 Jul 13;38(1):60-78.e12
pubmed: 32473656
Cell. 2019 Oct 3;179(2):403-416.e23
pubmed: 31585080
J Thorac Oncol. 2018 Feb;13(2):148-150
pubmed: 29425612
Cancer Cell. 2019 Jul 8;36(1):17-34.e7
pubmed: 31287989
Nucleic Acids Res. 2019 Jan 8;47(D1):D330-D338
pubmed: 30395331
J Clin Invest. 2019 Jun 4;129(9):3594-3609
pubmed: 31162144
Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14788-93
pubmed: 25267614
Dev Biol. 2012 Jan 1;361(1):103-15
pubmed: 22037235
Cancer Res. 1985 Jun;45(6):2913-23
pubmed: 2985257
Eur J Cell Biol. 2012 Jun-Jul;91(6-7):552-66
pubmed: 21982586

Auteurs

Ling Cai (L)

Quantitative Biomedical Research Center, Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, TX, USA. Ling.Cai@UTSouthwestern.edu.
Children's Research Institute, UT Southwestern Medical Center, Dallas, TX, USA. Ling.Cai@UTSouthwestern.edu.
Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA. Ling.Cai@UTSouthwestern.edu.

Hongyu Liu (H)

Quantitative Biomedical Research Center, Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, TX, USA.
Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China.

Fang Huang (F)

Children's Research Institute, UT Southwestern Medical Center, Dallas, TX, USA.

Junya Fujimoto (J)

Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Luc Girard (L)

Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA.
Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA.
Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX, USA.

Jun Chen (J)

Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China.
Department of Lung Cancer Surgery, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China.

Yongwen Li (Y)

Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China.
ORCID: 0000-0001-6102-2949

Yu-An Zhang (YA)

Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA.

Dhruba Deb (D)

Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA.

Victor Stastny (V)

Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA.

Karine Pozo (K)

Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.

Christin S Kuo (CS)

Department of Pediatrics, Stanford University, Stanford, CA, USA.

Gaoxiang Jia (G)

Quantitative Biomedical Research Center, Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, TX, USA.

Chendong Yang (C)

Children's Research Institute, UT Southwestern Medical Center, Dallas, TX, USA.

Wei Zou (W)

Department of Oncology Biomarker Development, Genentech Inc., South San Francisco, CA, USA.

Adeeb Alomar (A)

Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA.

Kenneth Huffman (K)

Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA.

Mahboubeh Papari-Zareei (M)

Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA.

Lin Yang (L)

Department of Pathology, National Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Benjamin Drapkin (B)

Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA.
Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA.
Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.

Esra A Akbay (EA)

Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA.
ORCID: 0000-0002-4149-2529

David S Shames (DS)

Department of Oncology Biomarker Development, Genentech Inc., South San Francisco, CA, USA.

Ignacio I Wistuba (II)

Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Tao Wang (T)

Quantitative Biomedical Research Center, Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, TX, USA.
Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA.
ORCID: 0000-0002-4355-149X

Jane E Johnson (JE)

Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA.
Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX, USA.
Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA.
ORCID: 0000-0002-8605-2746

Guanghua Xiao (G)

Quantitative Biomedical Research Center, Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, TX, USA.
Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA.
Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA.

Ralph J DeBerardinis (RJ)

Children's Research Institute, UT Southwestern Medical Center, Dallas, TX, USA.
Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA.
Howard Hughes Medical Institute, UT Southwestern Medical Center, Dallas, TX, USA.
ORCID: 0000-0002-2705-7432

John D Minna (JD)

Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA. John.Minna@UTSouthwestern.edu.
Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA. John.Minna@UTSouthwestern.edu.
Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX, USA. John.Minna@UTSouthwestern.edu.
Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA. John.Minna@UTSouthwestern.edu.
ORCID: 0000-0002-7776-0767

Yang Xie (Y)

Quantitative Biomedical Research Center, Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, TX, USA. Yang.Xie@UTSouthwestern.edu.
Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA. Yang.Xie@UTSouthwestern.edu.
Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA. Yang.Xie@UTSouthwestern.edu.

Adi F Gazdar (AF)

Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA.
Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA.
Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Cell-autonomous immune gene expression is...
Recherchemedicale.com › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Cell-autonomous immune gene expression is...
Recherchemedicale.com › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Cell-autonomous immune gene expression is...
Recherchemedicale.com › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Cell-autonomous immune gene expression is...
Recherchemedicale.com › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Lignage cellulaire › Cell-autonomous immune gene expression is...
Recherchemedicale.com › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › Cell-autonomous immune gene expression is...
Recherchemedicale.com › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Cell-autonomous immune gene expression is...
Recherchemedicale.com › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Cell-autonomous immune gene expression is...
Recherchemedicale.com › Phénomènes du système immunitaire › Phénomènes immunogénétiques › Complexe majeur d'histocompatibilité › Gènes MHC de classe I › Cell-autonomous immune gene expression is...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cell-autonomous immune gene expression is...
Recherchemedicale.com › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Immunophénotypage › Cell-autonomous immune gene expression is...
Recherchemedicale.com › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Cell-autonomous immune gene expression is...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Cell-autonomous immune gene expression is...
Recherchemedicale.com › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroendocrines › Cell-autonomous immune gene expression is...
Recherchemedicale.com › Phénomènes génétiques › Phénotype › Cell-autonomous immune gene expression is...
Recherchemedicale.com › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire à petites cellules › Cell-autonomous immune gene expression is...
Recherchemedicale.com › Phénomènes génétiques › Structures génétiques › Transcriptome › Cell-autonomous immune gene expression is...
Recherchemedicale.com › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Cell-autonomous immune gene expression is...
Recherchemedicale.com › Techniques d'investigation › Transplantation tumorale › Tests d'activité antitumorale sur modèle de xénogreffe › Cell-autonomous immune gene expression is...