Igf signaling couples retina growth with body growth by modulating progenitor cell division.
Animals
Animals, Genetically Modified
Cell Cycle
Cell Differentiation
/ physiology
Cell Division
/ physiology
Cell Proliferation
Cell Self Renewal
Insulin-Like Growth Factor I
/ genetics
Neurogenesis
Oryzias
/ embryology
Receptor, IGF Type 1
/ genetics
Retina
/ cytology
Signal Transduction
Stem Cell Niche
Stem Cells
/ cytology
Vertebrates
Medaka
Organ size
Scaling
Self-organization
Journal
Development (Cambridge, England)
ISSN: 1477-9129
Titre abrégé: Development
Pays: England
ID NLM: 8701744
Informations de publication
Date de publication:
01 04 2021
01 04 2021
Historique:
received:
02
12
2020
accepted:
04
03
2021
pubmed:
17
3
2021
medline:
18
9
2021
entrez:
16
3
2021
Statut:
ppublish
Résumé
How the body and organs balance their relative growth is of key importance for coordinating size and function. This is of particular relevance in organisms, which continue to grow over their entire life span. We addressed this issue in the neuroretina of medaka fish (Oryzias latipes), a well-studied system with which to address vertebrate organ growth. We reveal that a central growth regulator, Igf1 receptor (Igf1r), is necessary and sufficient for proliferation control in the postembryonic retinal stem cell niche: the ciliary marginal zone (CMZ). Targeted activation of Igf1r signaling in the CMZ uncouples neuroretina growth from body size control, and we demonstrate that Igf1r operates on progenitor cells, stimulating their proliferation. Activation of Igf1r signaling increases retinal size while preserving its structural integrity, revealing a modular organization in which progenitor differentiation and neurogenesis are self-organized and highly regulated. Our findings position Igf signaling as a key module for controlling retinal size and composition, with important evolutionary implications.
Identifiants
pubmed: 33722901
pii: dev.199133
doi: 10.1242/dev.199133
pmc: PMC8077508
pii:
doi:
Substances chimiques
Insulin-Like Growth Factor I
67763-96-6
Receptor, IGF Type 1
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2021. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interests The authors declare no competing or financial interests.
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