Differential impacts of postoperative complications on patients' survival in completely resected non-small-cell lung cancer.
Complication
Long-term effect
Non-small cell lung cancer
Overall survival
Thoracic surgery
Journal
General thoracic and cardiovascular surgery
ISSN: 1863-6713
Titre abrégé: Gen Thorac Cardiovasc Surg
Pays: Japan
ID NLM: 101303952
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
06
01
2021
accepted:
03
03
2021
pubmed:
10
3
2021
medline:
7
8
2021
entrez:
9
3
2021
Statut:
ppublish
Résumé
The aim of this study was to investigate the effects of inflammatory respiratory complications on long-term survival in patients with resected non-small cell lung cancer. We defined inflammatory respiratory complications to include the following six conditions: pneumonia, empyema, bronchial fistula, respiratory dysfunction, acute interstitial pneumonia, and atelectasis. Part of the National Clinical Database was linked to our prospective database from 2014 to 2017. Linkage was achieved for 866 patients. The Kaplan-Meier method was used to evaluate the overall, relapse-free, and cancer-related survival. The Cox proportional hazard model was used to analyze the impact of each complication. Of the 736 patients included in the study, 149 had complications. The 5-year overall and cancer-specific survival rates were significantly lower in patients with inflammatory respiratory complications. The Cox proportional hazard model showed that the inflammatory respiratory complications had a significant impact on overall survival (hazard ratio 2.48, 95% confidence interval 1.41-4.38) but not air leak (hazard ratio 1.38, 95% confidence interval 0.70-2.70). Our study shows the differential impact of each complication on the survival of patients with non-small cell lung cancer. The presence of inflammatory respiratory complications was the only predictor of poor overall survival.
Identifiants
pubmed: 33687642
doi: 10.1007/s11748-021-01619-z
pii: 10.1007/s11748-021-01619-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1283-1290Informations de copyright
© 2021. The Japanese Association for Thoracic Surgery.
Références
Agostini P, Cieslik H, Rathinam S, Bishay E, Kalkat MS, Rajesh PB, et al. Postoperative pulmonary complications following thoracic surgery: are there any modifiable risk factors? Thorax. 2010;65:815–8.
doi: 10.1136/thx.2009.123083
Chen-Yoshikawa TF, Fukui T, Nakamura S, Ito T, Kadomatsu Y, Tsubouchi H, et al. Current trends in thoracic surgery. Nagoya J Med Sci. 2020;82:161–74.
pubmed: 32581397
pmcid: 7276403
Thorpe A, Rodrigues J, Kavanagh J, Batchelor T, Lyen S. Postoperative complications of pulmonary resection. Clin Radiol. 2020;75(876):e1-15.
Andalib A, Ramana-Kumar AV, Bartlett G, Franco EL, Ferri LE. Influence of postoperative infectious complications on long-term survival of lung cancer patients: a population-based cohort study. J Thorac Oncol. 2013;8:554–61.
doi: 10.1097/JTO.0b013e3182862e7e
Fernandez FG, Kosinski AS, Furnary AP, Onaitis M, Kim S, Habib RH, et al. Differential effects of operative complications on survival after surgery for primary lung cancer. J Thorac Cardiovasc Surg. 2018;155(1254–64):e1251.
Baigrie RJ, Lamont PM, Kwiatkowski D, Dallman MJ, Morris PJ. Systemic cytokine response after major surgery. Br J Surg. 1992;79:757–60.
doi: 10.1002/bjs.1800790813
Harmey JH, Bucana CD, Lu W, Byrne AM, McDonnell S, Lynch C, et al. Lipopolysaccharide-induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion. Int J Cancer. 2002;101:415–22.
doi: 10.1002/ijc.10632
Gotoh M, Miyata H, Hashimoto H, Wakabayashi G, Konno H, Miyakawa S, et al. National Clinical Database feedback implementation for quality improvement of cancer treatment in Japan: from good to great through transparency. Surg Today. 2016;46:38–47.
doi: 10.1007/s00595-015-1146-y
Miyata H, Gotoh M, Hashimoto H, Motomura N, Murakami A, Tomotaki A, et al. Challenges and prospects of a clinical database linked to the board certification system. Surg Today. 2014;44:1991–9.
doi: 10.1007/s00595-013-0802-3
Endo S, Ikeda N, Kondo T, Nakajima J, Kondo H, Yokoi K, et al. Development of an annually updated Japanese national clinical database for chest surgery in 2014. Gen Thorac Cardiovasc Surg. 2016;64:569–76.
doi: 10.1007/s11748-016-0697-1
Goldstraw P, Crowley J, Chansky K, Giroux DJ, Groome PA, Rami-Porta R, et al. The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours. J Thorac Oncol. 2007;2:706–14.
doi: 10.1097/JTO.0b013e31812f3c1a
Lugg ST, Agostini PJ, Tikka T, Kerr A, Adams K, Bishay E, et al. Long-term impact of developing a postoperative pulmonary complication after lung surgery. Thorax. 2016;71:171–6.
doi: 10.1136/thoraxjnl-2015-207697
Nojiri T, Hamasaki T, Inoue M, Shintani Y, Takeuchi Y, Maeda H, et al. Long-term impact of postoperative complications on cancer recurrence following lung cancer surgery. Ann Surg Oncol. 2017;24:1135–42.
doi: 10.1245/s10434-016-5655-8
Rueth NM, Parsons HM, Habermann EB, Groth SS, Virnig BA, Tuttle TM, et al. The long-term impact of surgical complications after resection of stage I nonsmall cell lung cancer: a population-based survival analysis. Ann Surg. 2011;254:368–74.
doi: 10.1097/SLA.0b013e31822150fe
Okada S, Shimada J, Kato D, Tsunezuka H, Teramukai S, Inoue M. Long-term prognostic impact of severe postoperative complications after lung cancer surgery. Ann Surg Oncol. 2019;26:230–7.
doi: 10.1245/s10434-018-7061-x
Shinohara S, Kobayashi K, Kasahara C, Onitsuka T, Matsuo M, Nakagawa M, et al. Long-term impact of complications after lung resections in non-small cell lung cancer. J Thorac Dis. 2019;11:2024–33.
doi: 10.21037/jtd.2019.04.91
Wang S, Li X, Li Y, Li J, Jiang G, Liu J, et al. The long-term impact of postoperative pulmonary complications after video-assisted thoracic surgery lobectomy for lung cancer. J Thorac Dis. 2017;9:5143–52.
doi: 10.21037/jtd.2017.10.144
Beecher SM, O’Leary DP, McLaughlin R, Kerin MJ. The impact of surgical complications on cancer recurrence rates: a literature review. Oncol Res Treat. 2018;41:478–82.
doi: 10.1159/000487510
Cheng X, Chen H. Commentary on the impacts of postoperative complications on survival after lung cancer surgery. J Thorac Cardiovasc Surg. 2018;155:1265–6.
doi: 10.1016/j.jtcvs.2017.10.122