Wound healing performance of PCL/chitosan based electrospun nanofiber electrosprayed with curcumin loaded chitosan nanoparticles.
Animals
Anti-Bacterial Agents
/ chemistry
Antioxidants
/ chemistry
Biocompatible Materials
/ chemistry
Cell Line
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Chitosan
/ chemistry
Curcumin
/ chemistry
Escherichia coli
/ drug effects
Humans
Male
Methicillin-Resistant Staphylococcus aureus
/ drug effects
Mice
Nanofibers
/ chemistry
Nanoparticles
/ chemistry
Polyesters
/ chemistry
Tensile Strength
Wound Healing
/ drug effects
Chitosan
Curcumin
Curcumin loaded chitosan nano-encapsulated particles (CURCSNPs)
Electrospraying
Electrospun nanofiber
Poly(ε-caprolactone)
Journal
Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156
Informations de publication
Date de publication:
01 May 2021
01 May 2021
Historique:
received:
12
10
2020
revised:
27
11
2020
accepted:
09
01
2021
pubmed:
7
3
2021
medline:
15
4
2021
entrez:
6
3
2021
Statut:
ppublish
Résumé
In this study, the electrospun poly(ε-caprolactone) (PCL)/Chitosan (CS)/curcumin (CUR) nanofiber was fabricated successfully with curcumin loaded chitosan nano-encapsulated particles (CURCSNPs). The morphology of the produced CURCSNPs, PCL, PCL/CS, PCL/CS/CUR, and PCL/CS/CUR electrosprayed with CURCSNPs were analyzed by scanning electron microscopy (SEM). The physicochemical properties and biological characteristics of fabricated nanofibers such as antibacterial, antioxidant, cell viability, and in vivo wound healing efficiency and histological assay were tested. The electrospraying of CURCSNPs on surface PCL/CS/CUR nanofiber resulted in the enhanced antibacterial, antioxidant, cell proliferation efficiencies and higher swelling and water vapor transition rates. In vivo examination and Histological analysis showed PCL/CS/CUR electrosprayed with CURCSNPs led to significant improvement of complete well-organized wound healing process in MRSA infected wounds. These results suggest that the application of PCL/CS/CUR electrosprayed with CURCSNPs as a wound dressing significantly facilitates wound healing with notable antibacterial, antioxidant, and cell proliferation properties.
Identifiants
pubmed: 33673981
pii: S0144-8617(21)00028-X
doi: 10.1016/j.carbpol.2021.117640
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antioxidants
0
Biocompatible Materials
0
Polyesters
0
polycaprolactone
24980-41-4
Chitosan
9012-76-4
Curcumin
IT942ZTH98
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
117640Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.