Altered in vivo brain GABA and glutamate levels are associated with multiple sclerosis central fatigue.

Brain / diagnostic imaging Fatigue Glutamic Acid Glutamine Humans Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Multiple Sclerosis / complications gamma-Aminobutyric Acid
MS fatigue Magnetic resonance imaging Magnetic resonance spectroscopy Mescher-Garwood point resolved spectroscopy Neurometabolites

Journal

European journal of radiology
ISSN: 1872-7727
Titre abrégé: Eur J Radiol
Pays: Ireland
ID NLM: 8106411

Informations de publication

Date de publication:
Apr 2021
Historique:
received: 09 09 2020
revised: 31 01 2021
accepted: 21 02 2021
pubmed: 4 3 2021
medline: 15 4 2021
entrez: 3 3 2021
Statut: ppublish

Résumé

Fatigue is a common symptom in patients with multiple sclerosis (MS) with unknown pathophysiology. Dysfunction of the GABAergic/glutamatergic pathways involving inhibitory and excitatory neurotransmitters such as  γ-aminobutyric acid (GABA) and glutamine + glutamate pool (Glx) have been implicated in several neurological disorders. This study is aimed to evaluate the potential role of GABA and Glx in the origin of central fatigue in relapse remitting MS (RRMS) patients. 24 RRMS patients and 16 age- and sex-matched healthy controls (HC) were scanned using Mescher-Garwood point resolved spectroscopy (MEGA-PRESS) with a 3 T system to quantify GABA+ and Glx from prefrontal (PFC) and sensorimotor (SMC) cortices. Self-reported fatigue status was measured on all participants using the Modified Fatigue Impact Scale (MFIS). RRMS patients had higher fatigue scores relative to HC (p ≤  0.05). Compared to HC, Glx levels in RRMS patients were significantly decreased in SMC (p =  0.04). Significant correlations were found between fatigue scores and GABA+ (r = -0.531, p =  0.008) and Glx (r = 0.511, p =  0.018) in PFC. Physical fatigue was negatively correlated with GABA+ in SMC and PFC (r = -0.428 and -0.472 respectively, p ≤  0.04) and positively with PFC Glx (r = 0.480, p =  0.028). The associations between fatigue and GABA + and Glx suggest that there might be dysregulation of GABAergic/glutamatergic neurotransmission in the pathophysiological mechanism of central fatigue in MS.

Identifiants

DOI: 10.1016/j.ejrad.2021.109610 PMID: 33657474 PMC: PMC8900256
pubmed: 33657474
pii: S0720-048X(21)00090-5
doi: 10.1016/j.ejrad.2021.109610
pmc: PMC8900256
mid: NIHMS1781328
pii:
doi:

Substances chimiques

Glutamine 0RH81L854J
Glutamic Acid 3KX376GY7L
gamma-Aminobutyric Acid 56-12-2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109610

Subventions

Organisme : NIA NIH HHS
ID : K99 AG062230
Pays : United States

Informations de copyright

Crown Copyright © 2021. Published by Elsevier B.V. All rights reserved.

Références

Neuroradiology. 2008 Jan;50(1):17-23
pubmed: 17955232
J Nucl Med. 2014 Jun;55(6):945-50
pubmed: 24665088
Brain Sci. 2017 Aug 12;7(8):
pubmed: 28805691
Neuroimage. 2017 Aug 15;157:705-715
pubmed: 28131894
Biol Sex Differ. 2019 Jan 14;10(1):5
pubmed: 30642393
Eur Radiol. 2018 Mar;28(3):1140-1148
pubmed: 28986640
AJNR Am J Neuroradiol. 2013 Sep;34(9):1733-9
pubmed: 23493890
PLoS One. 2016 Feb 19;11(2):e0149622
pubmed: 26895076
Ann Neurol. 2006 Mar;59(3):478-89
pubmed: 16392116
Diagnostics (Basel). 2018 Jun 21;8(3):
pubmed: 29933643
J Neurol Sci. 2019 May 15;400:52-71
pubmed: 30903860
Neurochem Res. 2014 Jan;39(1):1-36
pubmed: 24258018
Brain. 2015 Sep;138(Pt 9):2467-8
pubmed: 26304149
Arch Neurol. 2004 Feb;61(2):201-7
pubmed: 14967766
Brain. 1997 Feb;120 ( Pt 2):299-315
pubmed: 9117377
JAMA Neurol. 2014 Jul 1;71(7):840-7
pubmed: 24839987
J Behav Med. 2017 Oct;40(5):772-783
pubmed: 28281106
Neuroscience. 2014 Jul 25;273:24-38
pubmed: 24814730
Neuroimage. 2001 Jun;13(6 Pt 1):1186-92
pubmed: 11352624
Neuroimage. 2012 Feb 15;59(4):3774-83
pubmed: 22119648
NMR Biomed. 2000 May;13(3):129-53
pubmed: 10861994
J Neurol Neurosurg Psychiatry. 2010 Jun;81(6):602-7
pubmed: 19965841
J Magn Reson Imaging. 2010 Jan;31(1):204-9
pubmed: 20027589
J Neural Transm (Vienna). 2017 Jul;124(7):775-798
pubmed: 28236206
Behav Neurosci. 2010 Jun;124(3):329-36
pubmed: 20528076
Expert Rev Neurother. 2010 Sep;10(9):1437-47
pubmed: 20819014
J Magn Reson Imaging. 2014 Dec;40(6):1445-52
pubmed: 25548816
Neurology. 1997 Jun;48(6):1566-71
pubmed: 9191767
Mult Scler. 2017 Apr;23(5):721-733
pubmed: 28206827
Radiol Med. 2012 Dec;117(8):1398-407
pubmed: 22729506
Neuroimage. 2017 Oct 1;159:32-45
pubmed: 28716717
Mult Scler Relat Disord. 2013 Oct;2(4):362-9
pubmed: 25877847
Sci Rep. 2016 Oct 11;6:34990
pubmed: 27725700
Neuroimage. 2002 Sep;17(1):479-89
pubmed: 12482100
Magn Reson Med. 2015 Jan;73(1):44-50
pubmed: 24436292
Neuroscientist. 2002 Dec;8(6):562-73
pubmed: 12467378
Int J MS Care. 2013 Spring;15(1):15-20
pubmed: 24453758
Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2580-5
pubmed: 20133656
Front Neurol. 2019 Nov 15;10:1173
pubmed: 31803127
Brain. 2005 May;128(Pt 5):1016-25
pubmed: 15758036
Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Jan;2(1):38-44
pubmed: 28217759
Neuroimage. 2011 Jun 1;56(3):907-22
pubmed: 21352927
J Neurosci. 2016 Nov 16;36(46):11788-11794
pubmed: 27852785
Mult Scler. 2014 Feb;20(2):192-201
pubmed: 23812284
Brain. 2015 Sep;138(Pt 9):2584-95
pubmed: 26304151
Neurol Res. 2017 Apr;39(4):323-330
pubmed: 28191860
J Neurosci Res. 2007 Aug 1;85(10):2059-70
pubmed: 17497670
Hum Brain Mapp. 2011 May;32(5):828-33
pubmed: 20645307
Neuroimage. 2014 Feb 1;86:43-52
pubmed: 23246994
J Neurol Sci. 1998 Oct 8;160(2):164-70
pubmed: 9849800
J Neurol Sci. 2014 Apr 15;339(1-2):35-40
pubmed: 24468541
Medicine (Baltimore). 2017 Apr;96(14):e6534
pubmed: 28383419
Neuroimage. 2015 Jan 15;105:67-75
pubmed: 25462698
Dis Markers. 2015;2015:758314
pubmed: 25722532
Neural Plast. 2015;2015:616242
pubmed: 26236509
J Neurol Neurosurg Psychiatry. 2014 Aug;85(8):833-9
pubmed: 24431465

Auteurs

Jameen Arm (J)

School of Health Sciences, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, 2308, Australia; Hunter Medical Research Institute, 1 Kookaburra Circuit, New Lambton, NSW, 2305, Australia.

Georg Oeltzschner (G)

The Russell H. Morgan Department of Radiology and Radiological Science, the Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore MD, USA.

Oun Al-Iedani (O)

School of Health Sciences, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, 2308, Australia; Hunter Medical Research Institute, 1 Kookaburra Circuit, New Lambton, NSW, 2305, Australia.

Rod Lea (R)

Hunter Medical Research Institute, 1 Kookaburra Circuit, New Lambton, NSW, 2305, Australia; Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.

Jeannette Lechner-Scott (J)

Hunter Medical Research Institute, 1 Kookaburra Circuit, New Lambton, NSW, 2305, Australia; Department of Neurology, John Hunter Hospital, New Lambton Heights, Newcastle, 2305, Australia; School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, 2308, Australia.

Saadallah Ramadan (S)

School of Health Sciences, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, 2308, Australia; Hunter Medical Research Institute, 1 Kookaburra Circuit, New Lambton, NSW, 2305, Australia. Electronic address: Saadallah.ramadan@newcastle.edu.au.

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Classifications MeSH

Recherchemedicale.com › Système nerveux › Système nerveux central › Encéphale › Altered in vivo brain GABA and glutamate...
Recherchemedicale.com › États, signes et symptômes pathologiques › Signes et symptômes › Fatigue › Altered in vivo brain GABA and glutamate...
Recherchemedicale.com › Acides aminés, peptides et protéines › Acides aminés › Acides aminés excitateurs › Acide glutamique › Altered in vivo brain GABA and glutamate...
Recherchemedicale.com › Acides aminés, peptides et protéines › Acides aminés › Acides aminés neutres › Glutamine › Altered in vivo brain GABA and glutamate...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Altered in vivo brain GABA and glutamate...
Recherchemedicale.com › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Altered in vivo brain GABA and glutamate...
Recherchemedicale.com › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Altered in vivo brain GABA and glutamate...
Recherchemedicale.com › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Altered in vivo brain GABA and glutamate...
Recherchemedicale.com › Acides aminés, peptides et protéines › Acides aminés › Amino-butyrates › Acide gamma-amino-butyrique › Altered in vivo brain GABA and glutamate...