Recurrent membranous nephropathy after transplantation: donor antigen and HLA converge in defining risk.
Journal
Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
18
10
2020
accepted:
29
10
2020
entrez:
27
2
2021
pubmed:
28
2
2021
medline:
6
3
2021
Statut:
ppublish
Résumé
Membranous nephropathy, like many forms of glomerulonephritis, is an HLA-associated autoimmune disease that can recur in the transplanted kidney. In this issue of Kidney International, Berchtold and colleagues publish an intriguing and important paper on risk factors for recurrent post-transplant membranous nephropathy due to autoimmunity to PLA2R1. They found that the genetics of both the autoantigen and donor HLA are important determinants of the risk of recurrent disease in the graft.
Identifiants
pubmed: 33637201
pii: S0085-2538(20)31415-0
doi: 10.1016/j.kint.2020.10.044
pii:
doi:
Substances chimiques
PLA2R1 protein, human
0
Receptors, Phospholipase A2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
545-548Commentaires et corrections
Type : CommentOn
Informations de copyright
Copyright © 2020 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.