Invisible leashes: The tethering VAPs from infectious diseases to neurodegeneration.
ALS
VAMP
endoplasmic reticulum
tethering proteins
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
Historique:
received:
22
12
2020
revised:
11
02
2021
accepted:
12
02
2021
pubmed:
21
2
2021
medline:
31
7
2021
entrez:
20
2
2021
Statut:
ppublish
Résumé
Intracellular organelles do not, as thought for a long time, act in isolation but are dynamically tethered together by entire machines responsible for interorganelle trafficking and positioning. Among the proteins responsible for tethering is the family of VAMP-associated proteins (VAPs) that appear in all eukaryotes and are localized primarily in the endoplasmic reticulum. The major functional role of VAPs is to tether the endoplasmic reticulum with different organelles and regulate lipid metabolism and transport. VAPs have gained increasing attention because of their role in human pathology where they contribute to infections by viruses and bacteria and participate in neurodegeneration. In this review, we discuss the structure, evolution, and functions of VAPs, focusing more specifically on VAP-B for its relationship with amyotrophic lateral sclerosis and other neurodegenerative diseases.
Identifiants
pubmed: 33609524
pii: S0021-9258(21)00194-0
doi: 10.1016/j.jbc.2021.100421
pmc: PMC8005810
pii:
doi:
Substances chimiques
VAPB protein, human
0
Vesicular Transport Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100421Subventions
Organisme : Medical Research Council
Pays : United Kingdom
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article.
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