Prolonged Systemic Inflammation Alters Muscarinic Long-Term Potentiation (mLTP) in the Hippocampus.
Animals
Cholinergic Agonists
/ pharmacology
Excitatory Postsynaptic Potentials
/ drug effects
Hippocampus
/ drug effects
Inflammation
/ chemically induced
Lipopolysaccharides
/ toxicity
Long-Term Potentiation
/ drug effects
Mice
Mice, Inbred BALB C
Neuronal Plasticity
/ drug effects
Organ Culture Techniques
Receptor, Muscarinic M1
/ agonists
Journal
Neural plasticity
ISSN: 1687-5443
Titre abrégé: Neural Plast
Pays: United States
ID NLM: 100883417
Informations de publication
Date de publication:
2021
2021
Historique:
received:
07
09
2020
revised:
30
12
2020
accepted:
05
01
2021
entrez:
29
1
2021
pubmed:
30
1
2021
medline:
28
10
2021
Statut:
epublish
Résumé
The cholinergic system plays a fundamental role in learning and memory. Pharmacological activation of the muscarinic receptor M1R potentiates NMDA receptor activity and induces short-term potentiation at the synapses called muscarinic LTP, mLTP. Dysfunction of cholinergic transmission has been detected in the settings of cognitive impairment and dementia. Systemic inflammation as well as neuroinflammation has been shown to profoundly alter synaptic transmission and LTP. Indeed, intervention which is aimed at reducing neuroinflammatory changes in the brain has been associated with an improvement in cognitive functions. While cognitive impairment caused either by cholinergic dysfunction and/or by systemic inflammation suggests a possible connection between the two, so far whether systemic inflammation affects mLTP has not been extensively studied. In the present work, we explored whether an acute versus persistent systemic inflammation induced by LPS injections would differently affect the ability of hippocampal synapses to undergo mLTP. Interestingly, while a short exposure to LPS resulted in a transient deficit in mLTP expression, a longer exposure persistently impaired mLTP. We believe that these findings may be involved in cognitive dysfunctions following sepsis and possibly neuroinflammatory processes.
Identifiants
pubmed: 33510779
doi: 10.1155/2021/8813734
pmc: PMC7822657
doi:
Substances chimiques
Cholinergic Agonists
0
Lipopolysaccharides
0
Receptor, Muscarinic M1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8813734Informations de copyright
Copyright © 2021 Efrat Shavit-Stein et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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