Recruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cord.
Afferent Pathways
/ physiopathology
Animals
Cervical Cord
/ cytology
Computer Simulation
Disease Models, Animal
Electrodes, Implanted
Epidural Space
Female
Ganglia, Spinal
/ cytology
Humans
Macaca fascicularis
Magnetic Resonance Imaging
Male
Models, Neurological
Motor Neurons
/ physiology
Muscle, Skeletal
/ innervation
Quadriplegia
/ etiology
Recruitment, Neurophysiological
/ physiology
Spinal Cord Injuries
/ complications
Spinal Cord Stimulation
/ instrumentation
Upper Extremity
/ innervation
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
19 01 2021
19 01 2021
Historique:
received:
16
02
2020
accepted:
16
12
2020
entrez:
20
1
2021
pubmed:
21
1
2021
medline:
2
2
2021
Statut:
epublish
Résumé
Epidural electrical stimulation (EES) of lumbosacral sensorimotor circuits improves leg motor control in animals and humans with spinal cord injury (SCI). Upper-limb motor control involves similar circuits, located in the cervical spinal cord, suggesting that EES could also improve arm and hand movements after quadriplegia. However, the ability of cervical EES to selectively modulate specific upper-limb motor nuclei remains unclear. Here, we combined a computational model of the cervical spinal cord with experiments in macaque monkeys to explore the mechanisms of upper-limb motoneuron recruitment with EES and characterize the selectivity of cervical interfaces. We show that lateral electrodes produce a segmental recruitment of arm motoneurons mediated by the direct activation of sensory afferents, and that muscle responses to EES are modulated during movement. Intraoperative recordings suggested similar properties in humans at rest. These modelling and experimental results can be applied for the development of neurotechnologies designed for the improvement of arm and hand control in humans with quadriplegia.
Identifiants
pubmed: 33469022
doi: 10.1038/s41467-020-20703-1
pii: 10.1038/s41467-020-20703-1
pmc: PMC7815834
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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