Growth hormone-releasing hormone agonists ameliorate chronic kidney disease-induced heart failure with preserved ejection fraction.
Animals
Blood Urea Nitrogen
Calcium
/ metabolism
Cardiotonic Agents
/ pharmacology
Connectin
/ genetics
Creatinine
/ blood
Disease Models, Animal
Female
Gene Expression Regulation
Growth Hormone-Releasing Hormone
/ agonists
Heart Failure
/ drug therapy
Myocytes, Cardiac
/ drug effects
Natriuretic Peptide, Brain
/ blood
Nephrectomy
/ methods
Peptide Fragments
/ blood
Protein Isoforms
/ genetics
Renal Insufficiency, Chronic
/ complications
Sermorelin
/ analogs & derivatives
Stroke Volume
/ physiology
Swine
cardiorenal syndrome
chronic kidney disease
heart failure with preserved ejection fraction
large animal model
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
26 01 2021
26 01 2021
Historique:
entrez:
20
1
2021
pubmed:
21
1
2021
medline:
10
6
2021
Statut:
ppublish
Résumé
Therapies for heart failure with preserved ejection fraction (HFpEF) are lacking. Growth hormone-releasing hormone agonists (GHRH-As) have salutary effects in ischemic and nonischemic heart failure animal models. Accordingly, we hypothesized that GHRH-A treatment ameliorates chronic kidney disease (CKD)-induced HFpEF in a large-animal model. Female Yorkshire pigs (
Identifiants
pubmed: 33468654
pii: 2019835118
doi: 10.1073/pnas.2019835118
pmc: PMC7848727
pii:
doi:
Substances chimiques
Cardiotonic Agents
0
Connectin
0
N-Me-Tyr1,D-Ala2,Asn8,Arg29-NHCH3-JI-38
0
Peptide Fragments
0
Protein Isoforms
0
pro-brain natriuretic peptide (1-76)
0
Natriuretic Peptide, Brain
114471-18-0
Sermorelin
86168-78-7
Growth Hormone-Releasing Hormone
9034-39-3
Creatinine
AYI8EX34EU
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL107110
Pays : United States
Organisme : NHLBI NIH HHS
ID : UM1 HL113460
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA136387
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134558
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600012C
Pays : United States
Déclaration de conflit d'intérêts
Competing interest statement: A.V.S and J.M.H. are listed as co-inventors on patents on GHRH analogs, which were assigned to the University of Miami and Veterans Affairs Department. J.M.H. previously owned equity in Biscayne Pharmaceuticals, licensee of intellectual property used in this study. Biscayne Pharmaceuticals did not provide funding for this study. J.M.H. is the chief scientific officer, a compensated consultant, and advisory board member for Longeveron and holds equity in Longeveron. J.M.H. is also the co-inventor of intellectual property licensed to Longeveron. Longeveron did not play a role in the design, conduct, or funding of the study. J.M.H.’s relationships are reported to the University of Miami, and an appropriate management plan is in place. I.H.S. contributed to this manuscript in her personal capacity. The opinions expressed in this article are the author's own and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government.
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