Multi-level remodelling of chromatin underlying activation of human T cells.
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Cells, Cultured
Chromatin
/ chemistry
Chromatin Assembly and Disassembly
/ genetics
Gene Expression Regulation, Developmental
/ genetics
Humans
Lymphocyte Activation
/ genetics
Male
Nucleosomes
/ genetics
T-Lymphocytes
/ immunology
Transcription Factors
Transcription, Genetic
/ genetics
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 01 2021
12 01 2021
Historique:
received:
01
12
2019
accepted:
15
12
2020
entrez:
13
1
2021
pubmed:
14
1
2021
medline:
31
8
2021
Statut:
epublish
Résumé
Remodelling of chromatin architecture is known to regulate gene expression and has been well characterized in cell lineage development but less so in response to cell perturbation. Activation of T cells, which triggers extensive changes in transcriptional programs, serves as an instructive model to elucidate how changes in chromatin architecture orchestrate gene expression in response to cell perturbation. To characterize coordinate changes at different levels of chromatin architecture, we analyzed chromatin accessibility, chromosome conformation and gene expression in activated human T cells. T cell activation was characterized by widespread changes in chromatin accessibility and interactions that were shared between activated CD4
Identifiants
pubmed: 33436846
doi: 10.1038/s41598-020-80165-9
pii: 10.1038/s41598-020-80165-9
pmc: PMC7804404
doi:
Substances chimiques
Chromatin
0
Nucleosomes
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
528Références
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