Impact of the clinical frailty scale on clinical outcomes and bleeding events in patients with ST-segment elevation myocardial infarction.
Aged
Female
Follow-Up Studies
Frailty
/ epidemiology
Humans
Incidence
Japan
/ epidemiology
Male
Middle Aged
Percutaneous Coronary Intervention
/ adverse effects
Postoperative Hemorrhage
/ epidemiology
Prospective Studies
Registries
Retrospective Studies
Risk Factors
ST Elevation Myocardial Infarction
/ complications
Time Factors
Bleeding events
Clinical frailty scale
Prognosis
ST-segment elevation myocardial infarction
Journal
Heart and vessels
ISSN: 1615-2573
Titre abrégé: Heart Vessels
Pays: Japan
ID NLM: 8511258
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
02
10
2020
accepted:
18
12
2020
pubmed:
8
1
2021
medline:
30
9
2021
entrez:
7
1
2021
Statut:
ppublish
Résumé
The Clinical Frailty Scale (CFS) is a simple tool to assess patients' frailty and may help to predict adverse outcomes in elderly patients. The aim of the present study was to examine the impact of CFS on clinical outcomes and bleeding events after successful percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI). We enrolled 266 consecutive patients with STEMI who underwent primary PCI in between January 2015 and June 2018. Patients were categorized into two groups based on the CFS stages: CFS 1-3 and CFS ≥ 4. We collected the data and evaluated the relationship between the CFS grade and the incidence of major adverse cardiovascular events (MACE) and Bleeding Academic Research Consortium 3 or 5 bleeding events. Of these patients, CFS ≥ 4 was present in 59 (22.2%). During the follow-up, 37.3% in the CFS ≥ 4 group and 8.2% in the CFS 1-3 group experienced MACE. In Kaplan-Meier analysis, the proportion of MACE-free survival for 4 years was significantly lower in the CFS ≥ 4 group (log-rank P < 0.001). Additionally, the proportion of bleeding event-free survival was significantly lower in the CFS ≥ 4 group (log-rank P < 0.001). The CFS (per 1-grade increase) remained an independent significant predictor of MACE on multivariate Cox proportional hazard analysis [hazard ratio 1.39 (95% confidence interval: 1.08 to 1.79, P = 0.01)]. In conclusion, CFS was an independent predictor of future adverse cardiac events in patients with STEMI. Therefore, the assessment of CFS is crucial in this population.
Identifiants
pubmed: 33411012
doi: 10.1007/s00380-020-01764-0
pii: 10.1007/s00380-020-01764-0
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
799-808Références
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