Acute interstitial nephritis and PR3-ANCA following reintroduction of pembrolizumab: a case report.
Acute Kidney Injury
/ chemically induced
Aged
Antibodies, Antineutrophil Cytoplasmic
/ blood
Antibodies, Monoclonal, Humanized
/ adverse effects
B7-H1 Antigen
/ metabolism
Female
Humans
Immune Checkpoint Inhibitors
/ adverse effects
Immunotherapy
/ adverse effects
Melanoma
/ drug therapy
Nephritis, Interstitial
/ chemically induced
Recurrence
Steroids
/ therapeutic use
Treatment Outcome
ANCA
acute interstitial nephritis
acute kidney injury
antineutrophil cytoplasmic antibody titer
immune checkpoint inhibitor
immunoassays
immunotherapy
immunotoxicity
pembrolizumab
proton pump inhibitor
Journal
Immunotherapy
ISSN: 1750-7448
Titre abrégé: Immunotherapy
Pays: England
ID NLM: 101485158
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
pubmed:
6
1
2021
medline:
3
2
2022
entrez:
5
1
2021
Statut:
ppublish
Résumé
Renal toxicity from immune checkpoint inhibitors (ICIs) is an increasingly recognized cause of acute kidney injury among patients with cancer. ICI-associated acute kidney injuries typically present as acute interstitial nephritis and the timing of onset is highly variable. Herein, we present a case of a patient with relapsed metastatic melanoma previously treated with pembrolizumab who developed grade 3 immune-related renal toxicity after reintroduction of the same ICI, secondary to acute interstitial nephritis with accompanying high PR3-antineutrophil cytoplasmic antibody titer. The patient improved after steroid treatment and discontinuation of pembrolizumab. This case highlights the importance of not excluding ICI-related nephrotoxicity as a possible cause of renal failure, including in those who previously tolerated ICI treatment, since it is a treatable entity.
Identifiants
pubmed: 33397120
doi: 10.2217/imt-2020-0223
doi:
Substances chimiques
Antibodies, Antineutrophil Cytoplasmic
0
Antibodies, Monoclonal, Humanized
0
B7-H1 Antigen
0
Immune Checkpoint Inhibitors
0
Steroids
0
pembrolizumab
DPT0O3T46P
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM