Rhinovirus-induced CCL17 and CCL22 in Asthma Exacerbations and Differential Regulation by STAT6.


Journal

American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225

Informations de publication

Date de publication:
03 2021
Historique:
pubmed: 3 12 2020
medline: 26 3 2021
entrez: 2 12 2020
Statut: ppublish

Résumé

The interplay of type-2 inflammation and antiviral immunity underpins asthma exacerbation pathogenesis. Virus infection induces type-2 inflammation-promoting chemokines CCL17 and CCL22 in asthma; however, mechanisms regulating induction are poorly understood. By using a human rhinovirus (RV) challenge model in human airway epithelial cells

Identifiants

pubmed: 33264064
doi: 10.1165/rcmb.2020-0011OC
pmc: PMC7909342
doi:

Substances chimiques

Biomarkers 0
CCL17 protein, human 0
CCL22 protein, human 0
Chemokine CCL17 0
Chemokine CCL22 0
Chemokines 0
NF-kappa B 0
STAT6 Transcription Factor 0
STAT6 protein, human 0

Types de publication

Clinical Trial Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

344-356

Subventions

Organisme : Medical Research Council
ID : G0601236
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1000758
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V000098/1
Pays : United Kingdom

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Auteurs

Teresa C Williams (TC)

School of Biomedical Science and Pharmacy, Faculty Health and Medicine and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, New South Wales, Australia.

David J Jackson (DJ)

Asthma UK Centre, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.
Guy's Severe Asthma Centre, Guy's & St. Thomas' National Health Service Trust, London, United Kingdom.

Steven Maltby (S)

School of Biomedical Science and Pharmacy, Faculty Health and Medicine and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, New South Wales, Australia.

Ross P Walton (RP)

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Yee-Mann Ching (YM)

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Nicholas Glanville (N)

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Aran Singanayagam (A)

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Jennifer J Brewins (JJ)

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Deborah Clarke (D)

National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Respiratory, Inflammation and Autoimmunity Department, MedImmune, Cambridge, United Kingdom.

Aurica G Hirsman (AG)

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Su-Ling Loo (SL)

School of Biomedical Science and Pharmacy, Faculty Health and Medicine and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, New South Wales, Australia.

Lan Wei (L)

School of Biomedical Science and Pharmacy, Faculty Health and Medicine and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, New South Wales, Australia.

Janine E Beale (JE)

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Paolo Casolari (P)

Interdepartmental Study Center for Inflammatory and Smoke-Related Airway Diseases, Cardiorespiratory and Internal Medicine Section, University of Ferrara, Ferrara, Italy.

Gaetano Caramori (G)

Interdepartmental Study Center for Inflammatory and Smoke-Related Airway Diseases, Cardiorespiratory and Internal Medicine Section, University of Ferrara, Ferrara, Italy.
Dipartimento di Scienze Biomediche, Pneumologia, Odontoiatriche e delle Immagini Morfologiche e Funzionali, Università degli Studi di Messina, Messina, Italy; and.

Alberto Papi (A)

Interdepartmental Study Center for Inflammatory and Smoke-Related Airway Diseases, Cardiorespiratory and Internal Medicine Section, University of Ferrara, Ferrara, Italy.

Maria Belvisi (M)

National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Respiratory, Inflammation and Autoimmunity Department, MedImmune, Cambridge, United Kingdom.

Peter A B Wark (PAB)

Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, New South Wales, Australia.

Sebastian L Johnston (SL)

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Michael R Edwards (MR)

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Nathan W Bartlett (NW)

School of Biomedical Science and Pharmacy, Faculty Health and Medicine and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, New South Wales, Australia.
National Heart and Lung Institute, Imperial College London, London, United Kingdom.

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Classifications MeSH