Oxidative stress mediated apoptotic potential of mefloquine on experimental trichinellosis.
Albendazole
/ therapeutic use
Animals
Anthelmintics
/ therapeutic use
Apoptosis
/ drug effects
Disease Models, Animal
Jejunum
/ parasitology
Larva
/ drug effects
Male
Mefloquine
/ therapeutic use
Mice
Muscles
/ parasitology
Oxidative Stress
/ drug effects
Reactive Oxygen Species
/ metabolism
Trichinella spiralis
/ drug effects
Trichinellosis
/ drug therapy
Albendazole
Apoptosis
Inflammation
Mefloquine
Oxidative stress
Trichinellosis
Journal
Acta tropica
ISSN: 1873-6254
Titre abrégé: Acta Trop
Pays: Netherlands
ID NLM: 0370374
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
10
02
2020
revised:
02
11
2020
accepted:
12
11
2020
pubmed:
23
11
2020
medline:
11
3
2021
entrez:
22
11
2020
Statut:
ppublish
Résumé
Conventional anthelmintics such as albendazole could not achieve complete cure of trichinellosis till now. The antimalarial mefloquine mediates oxidative stress and disrupts lysosomal functions leading to cell death. Therefore, the aim of this work was to investigate the effect of mefloquine on experimental acute and chronic trichinellosis and to clarify the possible mechanisms of such effects. Mice were divided into four groups; Group I: Uninfected untreated control (20 mice); Group II: Infected untreated control (40 mice); Group III: infected and treated with albendazole (400 mg/kg) (40 mice); Group IV: infected and treated with mefloquine (300 mg/kg) (40 mice). All infected treated groups were equally subdivided into 2 subgroups; (a) treated on the 2
Identifiants
pubmed: 33221280
pii: S0001-706X(20)31673-9
doi: 10.1016/j.actatropica.2020.105760
pii:
doi:
Substances chimiques
Anthelmintics
0
Reactive Oxygen Species
0
Albendazole
F4216019LN
Mefloquine
TML814419R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105760Informations de copyright
Copyright © 2020. Published by Elsevier B.V.