Elevated exercise ventilation in mild COPD is not linked to enhanced central chemosensitivity.
COPD
Chemoreception
Control of breathing
Dyspnea
Ventilation
Journal
Respiratory physiology & neurobiology
ISSN: 1878-1519
Titre abrégé: Respir Physiol Neurobiol
Pays: Netherlands
ID NLM: 101140022
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
03
07
2020
revised:
27
10
2020
accepted:
01
11
2020
pubmed:
9
11
2020
medline:
25
11
2021
entrez:
8
11
2020
Statut:
ppublish
Résumé
The purpose of this study was to determine if altered central chemoreceptor characteristics contributed to the elevated ventilation relative to carbon dioxide production (V̇ Twenty-nine mild COPD and 19 healthy age-matched control participants undertook lung function testing followed by symptom-limited incremental cardiopulmonary exercise testing . On a separate day, basal (non-chemoreflex) ventilation (V̇ At standardized exercise intensities, absolute V̇ These data have established that excessive exercise ventilation in mild COPD is not explained by altered central chemosensitivity.
Sections du résumé
BACKGROUND
The purpose of this study was to determine if altered central chemoreceptor characteristics contributed to the elevated ventilation relative to carbon dioxide production (V̇
METHODS
Twenty-nine mild COPD and 19 healthy age-matched control participants undertook lung function testing followed by symptom-limited incremental cardiopulmonary exercise testing . On a separate day, basal (non-chemoreflex) ventilation (V̇
RESULTS
At standardized exercise intensities, absolute V̇
CONCLUSION
These data have established that excessive exercise ventilation in mild COPD is not explained by altered central chemosensitivity.
Identifiants
pubmed: 33161118
pii: S1569-9048(20)30230-5
doi: 10.1016/j.resp.2020.103571
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103571Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.