Adjuvant Treatment Modalities, Prognostic Factors, and Outcome of the Uterine Carcinosarcoma.
Adult
Aged
Aged, 80 and over
Carcinosarcoma
/ pathology
Chemotherapy, Adjuvant
/ methods
Female
Humans
Middle Aged
Mixed Tumor, Mullerian
/ pathology
Neoplasm Recurrence, Local
/ epidemiology
Neoplasm Staging
Prognosis
Radiotherapy, Adjuvant
/ methods
Retrospective Studies
Treatment Outcome
Uterine Neoplasms
/ pathology
carcinosarcoma
mixed tumor, mullerian
radiotherapy
uterine neoplasms
Journal
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
ISSN: 1701-2163
Titre abrégé: J Obstet Gynaecol Can
Pays: Netherlands
ID NLM: 101126664
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
13
04
2020
revised:
20
06
2020
accepted:
24
06
2020
pubmed:
13
10
2020
medline:
1
7
2021
entrez:
12
10
2020
Statut:
ppublish
Résumé
To determine the impact of adjuvant therapy and other factors associated with the recurrence and survival of patients with uterine carcinosarcoma (UCS). A total of 102 patients who underwhent surgery for UCS from 1998 to 2017 were included in the analysis. Data were analyzed using Kaplan-Meier methods and Cox proportional hazards regression. At 240 months, the actuarial recurrence rate was 34.3%. Distant recurrence was the most common recurrence pattern. Patients with higher CA 125 levels, sarcoma dominance, cervical involvement, advanced stage, no lymphadenectomy, and residual tumour had a significiantly higher risk of recurrence. Five-year disease-free survival (DFS) and overall survival (OS) were 67% and 77%, respectively. FIGO stage was found to be an independent prognostic factor for DFS and OS. Sarcoma dominance was independently associated with decreased OS. Sarcoma dominance is associated with poor survival in UCS. Adjuvant treatment was not found to affect recurrence or survival. Given this finding, more effective postoperative strategies are needed.
Identifiants
pubmed: 33041218
pii: S1701-2163(20)30542-9
doi: 10.1016/j.jogc.2020.06.021
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
34-42Informations de copyright
Copyright © 2020 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gynécologues du Canada. Published by Elsevier Inc. All rights reserved.