Functional selective FPR1 signaling in favor of an activation of the neutrophil superoxide generating NOX2 complex.


Journal

Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628

Informations de publication

Date de publication:
06 2021
Historique:
revised: 20 08 2020
received: 20 05 2020
accepted: 08 09 2020
pubmed: 12 10 2020
medline: 31 8 2021
entrez: 11 10 2020
Statut: ppublish

Résumé

The formyl peptide receptors FPR1 and FPR2 are abundantly expressed by neutrophils, in which they regulate proinflammatory tissue recruitment of inflammatory cells, the production of reactive oxygen species (ROS), and resolution of inflammatory reactions. The unique dual functionality of the FPRs makes them attractive targets to develop FPR-based therapeutics as novel anti-inflammatory treatments. The small compound RE-04-001 has earlier been identified as an inducer of ROS in differentiated HL60 cells but the precise target and the mechanism of action of the compound was has until now not been elucidated. In this study, we reveal that RE-04-001 specifically targets and activates FPR1, and the concentrations needed to activate the neutrophil NADPH-oxidase was very low (EC

Identifiants

pubmed: 33040403
doi: 10.1002/JLB.2HI0520-317R
pmc: PMC8246850
doi:

Substances chimiques

FPR1 protein, human 0
Reactive Oxygen Species 0
Receptors, Formyl Peptide 0
Superoxides 11062-77-4
CYBB protein, human EC 1.6.3.-
NADPH Oxidase 2 EC 1.6.3.-
NADPH Oxidases EC 1.6.3.-
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1105-1120

Commentaires et corrections

Type : CommentIn

Informations de copyright

©2020 Society for Leukocyte Biology.

Références

Biochem Pharmacol. 2016 Aug 15;114:22-39
pubmed: 27131862
J Cell Sci. 2002 Feb 1;115(Pt 3):455-65
pubmed: 11861753
Immunol Rev. 2016 Jan;269(1):228-47
pubmed: 26683156
Biochim Biophys Acta. 2009 Jun;1793(6):933-40
pubmed: 19010359
Biochim Biophys Acta Mol Cell Res. 2018 May;1865(5):695-708
pubmed: 29477577
J Leukoc Biol. 2018 Dec;104(6):1117-1132
pubmed: 30134499
Ann Rheum Dis. 2017 Sep;76(9):1607-1613
pubmed: 28606963
Br J Clin Pharmacol. 2017 Mar;83(3):476-486
pubmed: 27730665
Antioxid Redox Signal. 2015 Aug 10;23(5):446-59
pubmed: 24359237
Virulence. 2019 Dec;10(1):610-624
pubmed: 31234710
Nat Commun. 2020 Mar 5;11(1):1208
pubmed: 32139677
Free Radic Biol Med. 2010 Dec 15;49(12):1834-45
pubmed: 20870019
Eur J Clin Invest. 2018 Nov;48 Suppl 2:e12967
pubmed: 29896919
Exp Cell Res. 2014 Apr 15;323(1):209-217
pubmed: 24491917
Curr Pharm Des. 2018;24(10):1100-1120
pubmed: 29611477
Basic Clin Pharmacol Toxicol. 2018 Feb;122(2):191-198
pubmed: 28881079
Eur J Haematol. 1993 Nov;51(5):288-93
pubmed: 8282090
Scand J Immunol. 1976 Jun;Suppl 5:9-15
pubmed: 1052391
Nat Genet. 2003 Jan;33(1):25-32
pubmed: 12461526
J Biol Chem. 2003 Aug 15;278(33):30578-86
pubmed: 12773548
Front Biosci (Landmark Ed). 2009 Jan 01;14:4546-56
pubmed: 19273369
Am J Respir Cell Mol Biol. 2018 Jun;58(6):745-755
pubmed: 29361236
Curr Hypertens Rep. 2012 Feb;14(1):70-8
pubmed: 22071588
Nat Commun. 2017 Feb 07;8:14232
pubmed: 28169296
J Biol Chem. 2016 Dec 9;291(50):26083-26097
pubmed: 27789711
Scand J Immunol. 2009 Oct;70(4):396-402
pubmed: 19751275
Sci Signal. 2018 Nov 06;11(555):
pubmed: 30401786
Cells. 2020 Apr 23;9(4):
pubmed: 32340221
Toxicol Appl Pharmacol. 2013 Aug 15;271(1):49-63
pubmed: 23680455
J Allergy Clin Immunol. 2008 Dec;122(6):1097-103
pubmed: 18823651
J Med Chem. 2020 Sep 10;63(17):9003-9019
pubmed: 32407089
Sci Signal. 2018 Sep 25;11(549):
pubmed: 30254056
Biochem Pharmacol. 2019 Aug;166:163-173
pubmed: 31085160
Methods Mol Biol. 2020;2087:301-324
pubmed: 31729000
Molecules. 2017 Mar 13;22(3):
pubmed: 28335409
J Leukoc Biol. 2021 Jun;109(6):1105-1120
pubmed: 33040403
Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12646-51
pubmed: 15310853
Eur J Pharmacol. 2006 Mar 18;534(1-3):1-11
pubmed: 16516193
Biochem Pharmacol. 2011 Feb 1;81(3):402-11
pubmed: 21095183
Expert Opin Ther Pat. 2016 Oct;26(10):1139-1156
pubmed: 27454150
Nat Commun. 2020 Feb 14;11(1):885
pubmed: 32060286
Trends Immunol. 2018 Oct;39(10):815-829
pubmed: 30195466
Expert Opin Drug Discov. 2017 May;12(5):511-523
pubmed: 28277837
Biochem J. 2003 Sep 1;374(Pt 2):281-96
pubmed: 12790797
Scand J Clin Lab Invest Suppl. 1968;97:77-89
pubmed: 4179068
Mol Pharmacol. 1986 Nov;30(5):437-43
pubmed: 2430168
Mol Biol Cell. 2011 Nov;22(21):3986-94
pubmed: 21880897
J Leukoc Biol. 2017 Sep;102(3):871-880
pubmed: 28760822
Infect Immun. 2012 Jun;80(6):1987-95
pubmed: 22431645
Nat Genet. 2017 Mar;49(3):433-437
pubmed: 28135245
Biochem Pharmacol. 2017 Dec 1;145:114-122
pubmed: 28855087
Mol Pharmacol. 2016 Nov;90(5):587-595
pubmed: 27638872
Free Radic Biol Med. 2018 Sep;125:62-71
pubmed: 29550327
Inflammation. 2007 Dec;30(6):224-9
pubmed: 17687636
ACS Pharmacol Transl Sci. 2020 Mar 11;3(2):203-220
pubmed: 32296763
Pharmacol Rev. 2009 Jun;61(2):119-61
pubmed: 19498085
Semin Immunol. 2016 Apr;28(2):137-45
pubmed: 27021499
FASEB J. 2019 Jun;33(6):6887-6903
pubmed: 30808243
PLoS One. 2013;8(3):e60169
pubmed: 23555913
Immunology. 2004 Jun;112(2):201-10
pubmed: 15147563
J Leukoc Biol. 2017 Jan;101(1):239-251
pubmed: 27493245
Clin Dev Immunol. 2013;2013:456407
pubmed: 24069041
Trends Mol Med. 2019 Oct;25(10):826-835
pubmed: 31303528
J Biol Chem. 2003 Oct 24;278(43):41581-4
pubmed: 12947104
Front Immunol. 2016 Apr 26;7:160
pubmed: 27199985
Eur J Immunol. 2007 Apr;37(4):1087-96
pubmed: 17330823
Thorax. 1994 Sep;49(9):867-71
pubmed: 7940424
J Mol Med (Berl). 2013 Jul;91(7):781-9
pubmed: 23404331
J Immunol. 2012 Jul 15;189(2):629-37
pubmed: 22706076
JACC Basic Transl Sci. 2019 Nov 13;4(8):905-920
pubmed: 31909300
Exp Cell Res. 2015 Aug 15;336(2):242-52
pubmed: 26192818
Biochim Biophys Acta Mol Cell Res. 2020 Jun;1867(6):118689
pubmed: 32092308
Front Immunol. 2017 Dec 21;8:1828
pubmed: 29375548
Mol Pharmacol. 2004 Nov;66(5):1213-22
pubmed: 15308762
J Autoimmun. 2017 Dec;85:64-77
pubmed: 28689639
BMC Cell Biol. 2004 May 24;5:21
pubmed: 15157285
J Immunol. 2019 Dec 15;203(12):3349-3360
pubmed: 31694908
J Cell Biol. 2002 Oct 14;159(1):91-102
pubmed: 12370241
J Immunol. 1982 Dec;129(6):2725-8
pubmed: 7142703
Biochim Biophys Acta Mol Cell Res. 2019 Feb;1866(2):305-316
pubmed: 30521870
Nat Rev Mol Cell Biol. 2018 Oct;19(10):638-653
pubmed: 30104700
Ann N Y Acad Sci. 2012 Aug;1266:63-7
pubmed: 22901257

Auteurs

Simon Lind (S)

Department of Rheumatology and Inflammation Research, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.

Claes Dahlgren (C)

Department of Rheumatology and Inflammation Research, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.

Rikard Holmdahl (R)

Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.

Peter Olofsson (P)

Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.

Huamei Forsman (H)

Department of Rheumatology and Inflammation Research, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH