The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.
Animals
CCAAT-Enhancer-Binding Protein-beta
/ metabolism
Cell Differentiation
Cell Line
Dendritic Cells
/ metabolism
Female
Gene Expression Regulation
Humans
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Monocytes
/ metabolism
Protein Isoforms
/ genetics
Signal Transduction
T-Lymphocytes
/ metabolism
TOR Serine-Threonine Kinases
/ metabolism
Transcription Factors
/ metabolism
Tumor Microenvironment
/ physiology
dendritic cell maturation
lymphoma–stroma interaction
transcription factor C/EBPβ
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
20 10 2020
20 10 2020
Historique:
pubmed:
7
10
2020
medline:
5
1
2021
entrez:
6
10
2020
Statut:
ppublish
Résumé
Dendritic cell (DC) maturation is a prerequisite for the induction of adaptive immune responses against pathogens and cancer. Transcription factor (TF) networks control differential aspects of early DC progenitor versus late-stage DC cell fate decisions. Here, we identified the TF C/EBPβ as a key regulator for DC maturation and immunogenic functionality under homeostatic and lymphoma-transformed conditions. Upon cell-specific deletion of C/EBPβ in CD11c
Identifiants
pubmed: 33020261
pii: 2008883117
doi: 10.1073/pnas.2008883117
pmc: PMC7584915
doi:
Substances chimiques
CCAAT-Enhancer-Binding Protein-beta
0
Protein Isoforms
0
Transcription Factors
0
mTOR protein, mouse
EC 2.7.1.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
26328-26339Déclaration de conflit d'intérêts
The authors declare no competing interest.
Références
J Biol Chem. 2007 Aug 24;282(34):24679-88
pubmed: 17599912
Cell. 1999 Oct 1;99(1):23-33
pubmed: 10520991
Mol Immunol. 2009 Mar;46(6):1229-39
pubmed: 19135256
Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6062-7
pubmed: 15075390
J Immunol. 2008 Mar 1;180(5):3019-27
pubmed: 18292524
Cytokine. 2011 Apr;54(1):6-19
pubmed: 21257317
Immunity. 2013 Jul 25;39(1):1-10
pubmed: 23890059
Immunol Rev. 2006 Apr;210:67-85
pubmed: 16623765
Trends Immunol. 2016 Dec;37(12):855-865
pubmed: 27793569
Immunity. 1996 Apr;4(4):357-66
pubmed: 8612130
Oncogene. 2007 Jan 25;26(4):509-20
pubmed: 16862181
Science. 2011 Mar 25;331(6024):1565-70
pubmed: 21436444
Blood. 2008 Jun 15;111(12):5562-70
pubmed: 18424665
Biochim Biophys Acta. 1997 Mar 14;1331(1):1-40
pubmed: 9325434
Blood. 2013 May 16;121(20):4073-81
pubmed: 23547051
J Exp Med. 2010 Apr 12;207(4):823-36
pubmed: 20351058
Cell Cycle. 2007 Apr 15;6(8):972-81
pubmed: 17404513
Immunity. 2010 Jun 25;32(6):790-802
pubmed: 20605485
J Immunol. 2010 Oct 1;185(7):3919-31
pubmed: 20805416
Nat Immunol. 2015 Jan;16(1):36-44
pubmed: 25521683
Nature. 1985 Dec 12-18;318(6046):533-8
pubmed: 3906410
Blood. 2003 Jun 1;101(11):4457-63
pubmed: 12531798
EMBO J. 2009 Jun 17;28(12):1769-81
pubmed: 19440205
Nat Rev Immunol. 2009 May;9(5):324-37
pubmed: 19390566
Nature. 2000 Mar 9;404(6774):193-7
pubmed: 10724173
J Immunol. 2010 Jun 1;184(11):6084-91
pubmed: 20421650
Nucleic Acids Res. 2012 Jan;40(Database issue):D1060-6
pubmed: 22110038
Semin Immunol. 2005 Aug;17(4):262-72
pubmed: 15946854
J Cell Mol Med. 2014 Sep;18(9):1908-12
pubmed: 24913604
Cell Signal. 2012 Jun;24(6):1287-96
pubmed: 22374303
Curr Opin Immunol. 2014 Apr;27:16-25
pubmed: 24531241
Blood. 2011 May 12;117(19):5157-65
pubmed: 21389327
J Cancer. 2013;4(1):36-44
pubmed: 23386903
Immunity. 2000 Mar;12(3):233-9
pubmed: 10755610
Cell. 1991 Nov 1;67(3):569-79
pubmed: 1934061
Immunity. 2014 May 15;40(5):642-56
pubmed: 24837101
Immunity. 2016 Oct 18;45(4):719-736
pubmed: 27760337
J Immunol. 1994 Jul 1;153(1):256-61
pubmed: 8207240
Cell Syst. 2015 Dec 23;1(6):417-425
pubmed: 26771021
Cell Biochem Funct. 2007 May-Jun;25(3):287-96
pubmed: 16927405
Front Immunol. 2015 Feb 04;6:35
pubmed: 25699051
Trends Cell Biol. 2007 Jul;17(7):318-24
pubmed: 17658261
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Mol Biol Cell. 2002 Jun;13(6):1977-2000
pubmed: 12058064
Nat Immunol. 2012 Dec;13(12):1145-54
pubmed: 23160217
Br J Haematol. 2002 Jun;117(3):727-34
pubmed: 12028050
Eur J Immunol. 2005 Oct;35(10):2851-63
pubmed: 16180253
Blood. 2006 Mar 1;107(5):2112-22
pubmed: 16269622
Cell. 1990 Nov 16;63(4):707-16
pubmed: 2121367
Genes Dev. 2010 Jan 1;24(1):15-20
pubmed: 20047998
Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1722-33
pubmed: 27386937
Immunity. 2017 May 16;46(5):849-862.e7
pubmed: 28514690
J Exp Med. 2007 Jan 22;204(1):171-80
pubmed: 17190836
Nat Commun. 2014 Sep 30;5:5057
pubmed: 25266931
Immunity. 2016 Sep 20;45(3):669-684
pubmed: 27637149
Eur J Immunol. 2006 Mar;36(3):631-47
pubmed: 16479545
Curr Opin Immunol. 2001 Feb;13(1):45-51
pubmed: 11154916
Annu Rev Immunol. 2012;30:1-22
pubmed: 22136168
J Cell Biol. 2017 Mar 6;216(3):779-792
pubmed: 28130292
Semin Immunol. 2011 Oct;23(5):388-97
pubmed: 21924924
J Immunol. 2012 Feb 15;188(4):1751-60
pubmed: 22262658
J Immunol. 2013 Nov 1;191(9):4665-75
pubmed: 24078688