Point of Care Diagnostics in Resource-Limited Settings: A Review of the Present and Future of PoC in Its Most Needed Environment.
bottlenecks to usage by patients
low-income countries
point of care diagnostics
resource-limited settings
Journal
Biosensors
ISSN: 2079-6374
Titre abrégé: Biosensors (Basel)
Pays: Switzerland
ID NLM: 101609191
Informations de publication
Date de publication:
24 Sep 2020
24 Sep 2020
Historique:
received:
27
08
2020
revised:
11
09
2020
accepted:
23
09
2020
entrez:
29
9
2020
pubmed:
30
9
2020
medline:
17
4
2021
Statut:
epublish
Résumé
Point of care (PoC) diagnostics are at the focus of government initiatives, NGOs and fundamental research alike. In high-income countries, the hope is to streamline the diagnostic procedure, minimize costs and make healthcare processes more efficient and faster, which, in some cases, can be more a matter of convenience than necessity. However, in resource-limited settings such as low-income countries, PoC-diagnostics might be the only viable route, when the next laboratory is hours away. Therefore, it is especially important to focus research into novel diagnostics for these countries in order to alleviate suffering due to infectious disease. In this review, the current research describing the use of PoC diagnostics in resource-limited settings and the potential bottlenecks along the value chain that prevent their widespread application is summarized. To this end, we will look at literature that investigates different parts of the value chain, such as fundamental research and market economics, as well as actual use at healthcare providers. We aim to create an integrated picture of potential PoC barriers, from the first start of research at universities to patient treatment in the field. Results from the literature will be discussed with the aim to bring all important steps and aspects together in order to illustrate how effectively PoC is being used in low-income countries. In addition, we discuss what is needed to improve the situation further, in order to use this technology to its fullest advantage and avoid "leaks in the pipeline", when a promising device fails to take the next step of the valorization pathway and is abandoned.
Identifiants
pubmed: 32987809
pii: bios10100133
doi: 10.3390/bios10100133
pmc: PMC7598644
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Nationaal Regieorgaan Praktijkgericht Onderzoek SIA
ID : SURFSCAN
Organisme : Worldwide Universities Network
ID : Research Mobility Program Grant Benjamin Heidt
Organisme : Province of Limburg
ID : Limburg Meet
Références
Open Forum Infect Dis. 2016 Jul 29;3(3):ofw161
pubmed: 27704016
Lab Chip. 2008 Dec;8(12):2015-31
pubmed: 19023464
Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):478-483
pubmed: 30598444
Biosens Bioelectron. 2018 Apr 30;103:138-142
pubmed: 29291593
Lancet. 2010 Oct 9;376(9748):1254-60
pubmed: 20934597
PLoS One. 2013;8(2):e55308
pubmed: 23405133
Biosens Bioelectron. 2017 Jan 15;87:949-956
pubmed: 27665517
Lancet. 2009 May 9;373(9675):1645-53
pubmed: 19427959
Exp Mol Pathol. 2012 Oct;93(2):261-3
pubmed: 22579954
BMC Med. 2016 Jul 07;14(1):102
pubmed: 27383644
J Immunol Methods. 2017 Sep;448:44-50
pubmed: 28529048
Lancet Diabetes Endocrinol. 2019 Feb;7(2):150-160
pubmed: 30072234
Int J Gynaecol Obstet. 2015 Jun;130 Suppl 1:S70-2
pubmed: 25968489
BMJ. 1990 Sep 1;301(6749):412-5
pubmed: 2282396
Bull World Health Organ. 2015 Feb 1;93(2):118-24
pubmed: 25883405
Int J Drug Policy. 2020 Jan;75:102613
pubmed: 31786434
PLoS One. 2017 Jul 27;12(7):e0182005
pubmed: 28750083
ACS Nano. 2014 May 27;8(5):5116-24
pubmed: 24779675
Clin Epidemiol. 2013 Sep 26;5:387-96
pubmed: 24124392
Biomed Res Int. 2017;2017:4765719
pubmed: 28133608
PLoS One. 2018 Mar 2;13(3):e0193577
pubmed: 29499042
Clin Med (Lond). 2014 Feb;14(1):6-12
pubmed: 24532735
Soc Sci Med. 2018 Apr;202:1-12
pubmed: 29499522
Afr J Lab Med. 2017 Sep 18;6(1):643
pubmed: 29159139
Biosensors (Basel). 2015 Aug 13;5(3):577-601
pubmed: 26287254
N Engl J Med. 2009 Apr 2;360(14):1385-94
pubmed: 19339719
PLoS One. 2015 Jul 30;10(7):e0134578
pubmed: 26226183
Acc Chem Res. 2015 Apr 21;48(4):911-20
pubmed: 25785632
AIDS. 2013 Jun 1;27(9):1483-92
pubmed: 23462219
Bull World Health Organ. 2008 Jul;86(7):516-523B
pubmed: 18670663
Trop Med Infect Dis. 2019 Mar 26;4(1):
pubmed: 30917506
Expert Rev Mol Diagn. 2015;15(9):1107-10
pubmed: 26312948
Trends Biotechnol. 2015 Nov;33(11):692-705
pubmed: 26463722
J Int AIDS Soc. 2015 Sep 04;18:20235
pubmed: 26344017
Lab Chip. 2007 May;7(5):547-9
pubmed: 17476371
Biosens Bioelectron. 2017 Jun 15;92:549-562
pubmed: 27836593
Sex Transm Infect. 2006 Dec;82 Suppl 5:v1-6
pubmed: 17151023
Diagnostics (Basel). 2017 Nov 29;7(4):
pubmed: 29186013
J Int AIDS Soc. 2019 Sep;22(9):e25337
pubmed: 31515967
Health Res Policy Syst. 2017 Jul 12;15(Suppl 1):47
pubmed: 28722558
Sens Actuators B Chem. 2016 Nov 01;235:126-135
pubmed: 27725788
Nat Rev Microbiol. 2006 Dec;4(12 Suppl):S7-19
pubmed: 17110922
Lancet. 2012 Aug 4;380(9840):507-35
pubmed: 22857974
PLoS One. 2019 Aug 26;14(8):e0221586
pubmed: 31449559
Methods Mol Biol. 2015;1256:277-89
pubmed: 25626546
BMC Cancer. 2017 Nov 25;17(1):791
pubmed: 29178896
Lab Chip. 2008 Dec;8(12):1982-3
pubmed: 19023459
Biosens Bioelectron. 2017 Feb 15;88:204-209
pubmed: 27567707
Biotechnol J. 2018 Jan;13(1):
pubmed: 29178532
Expert Rev Mol Diagn. 2016;16(4):449-59
pubmed: 26777725
Global Health. 2018 Jul 4;14(1):65
pubmed: 29973232
BMC Public Health. 2012 Nov 16;12:991
pubmed: 23158554
Philos Trans A Math Phys Eng Sci. 2017 Jun 13;375(2095):
pubmed: 28461436
Trans R Soc Trop Med Hyg. 2010 May;104(5):313-9
pubmed: 20138323
BMJ Glob Health. 2016 Dec 2;1(4):e000132
pubmed: 28588980
Biosens Bioelectron. 2018 Feb 15;100:85-88
pubmed: 28865242
Nature. 2006 Nov 23;444 Suppl 1:73-9
pubmed: 17159896
Biosens Bioelectron. 2017 Mar 15;89(Pt 2):998-1005
pubmed: 27825520
Biosensors (Basel). 2018 Nov 29;8(4):
pubmed: 30501052
Sex Transm Dis. 1999 Apr;26(4):232-40
pubmed: 10225593
Pharm Pat Anal. 2016 Sep;5(6):391-400
pubmed: 27813447
PLoS Med. 2012;9(9):e1001306
pubmed: 22973183
Med Biol Eng Comput. 2011 Jul;49(7):719-22
pubmed: 21597999
Lancet Glob Health. 2013 Oct;1(4):e184-5
pubmed: 25104343
Lancet Infect Dis. 2012 Aug;12(8):579-80
pubmed: 22704777
Trials. 2016 Sep 07;17(1):439
pubmed: 27604571
Lancet. 2009 May 9;373(9675):1584-5
pubmed: 19427941
Lab Chip. 2012 Jun 21;12(12):2118-34
pubmed: 22344520
N Engl J Med. 2012 Aug 9;367(6):485-8
pubmed: 22852882
PLoS Med. 2014 Sep 16;11(9):e1001725
pubmed: 25225800
Sensors (Basel). 2017 Nov 03;17(11):
pubmed: 29099764
Sensors (Basel). 2017 Nov 23;17(12):
pubmed: 29168733
PLoS Med. 2012;9(6):e1001233
pubmed: 22719229
J Clin Microbiol. 2017 Aug;55(8):2313-2320
pubmed: 28539345
Trop Med Int Health. 2011 Jan;16(1):37-41
pubmed: 21371207
Health Aff (Millwood). 2016 May 1;35(5):776-83
pubmed: 27140982
Int J Parasitol Drugs Drug Resist. 2014 Sep 19;4(3):220-5
pubmed: 25516832
Lancet. 2009 Jul 18;374(9685):201-2
pubmed: 19616718
Diagnostics (Basel). 2017 Jan 08;7(1):
pubmed: 28075337
BMC Health Serv Res. 2019 Jul 24;19(1):519
pubmed: 31340833
J Epidemiol Glob Health. 2012 Mar;2(1):39-50
pubmed: 23856397
PLoS One. 2016 Mar 31;11(3):e0152672
pubmed: 27032094
Am J Clin Pathol. 2010 Oct;134(4):568-72
pubmed: 20855637
BMC Health Serv Res. 2016 Aug 02;16(a):343
pubmed: 27484023
R Soc Open Sci. 2019 May 22;6(5):180421
pubmed: 31218015
Methods Inf Med. 2017 Aug 08;56(7):e105-e122
pubmed: 28925418
Diagnostics (Basel). 2015 May 19;5(2):200-9
pubmed: 26854149
Am J Clin Pathol. 2014 Jan;141(1):17-24
pubmed: 24343733
Int J Tuberc Lung Dis. 2012 Nov;16(11):1492-7
pubmed: 22964096
Micromachines (Basel). 2017 Oct 27;8(11):
pubmed: 30400509
BMC Med. 2011 May 20;9:59
pubmed: 21599888
Int J Health Serv. 2014;44(2):323-35
pubmed: 24919307
ACS Infect Dis. 2018 Aug 10;4(8):1162-1178
pubmed: 29860830
Sci Transl Med. 2015 Apr 15;7(283):283rv3
pubmed: 25877894
PLoS One. 2019 Oct 16;14(10):e0223669
pubmed: 31618220
Sex Transm Infect. 2017 Dec;93(S4):S69-S80
pubmed: 29223965