Zinc-pretreatment triggers glutathione and Nrf2-mediated protection against inorganic mercury-induced cytotoxicity and intrinsic apoptosis in PC12 cells.
Animals
Antioxidants
/ metabolism
Apoptosis
/ drug effects
Caspase 3
Cell Survival
/ drug effects
Glutathione
/ metabolism
Humans
Mercury
/ toxicity
NF-E2-Related Factor 2
/ metabolism
PC12 Cells
Proto-Oncogene Proteins c-bcl-2
Rats
Reactive Oxygen Species
/ metabolism
Signal Transduction
/ drug effects
Zinc
/ metabolism
Antioxidant
Cytochrome c
ERK1
Hemeoxygenese1
Oxidative stress
Journal
Ecotoxicology and environmental safety
ISSN: 1090-2414
Titre abrégé: Ecotoxicol Environ Saf
Pays: Netherlands
ID NLM: 7805381
Informations de publication
Date de publication:
01 Jan 2021
01 Jan 2021
Historique:
received:
25
05
2020
revised:
06
09
2020
accepted:
09
09
2020
pubmed:
19
9
2020
medline:
19
12
2020
entrez:
18
9
2020
Statut:
ppublish
Résumé
Mercury (Hg) is a hazardous metal, poses environmental problems with severe human health effects; whereas zinc (Zn) is an essential micronutrient with antioxidant properties. The purpose of this research was to investigate the effect of Zn on inorganic Hg-induced cytotoxicity in the PC12 cells. The cells were treated with HgCl
Identifiants
pubmed: 32947215
pii: S0147-6513(20)31157-X
doi: 10.1016/j.ecoenv.2020.111320
pii:
doi:
Substances chimiques
Antioxidants
0
BCL2 protein, human
0
NF-E2-Related Factor 2
0
NFE2L2 protein, human
0
Proto-Oncogene Proteins c-bcl-2
0
Reactive Oxygen Species
0
CASP3 protein, human
EC 3.4.22.-
Caspase 3
EC 3.4.22.-
Mercury
FXS1BY2PGL
Glutathione
GAN16C9B8O
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111320Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.