Sumatriptan improves the locomotor activity and neuropathic pain by modulating neuroinflammation in rat model of spinal cord injury.

Analgesics / pharmacology Animals Anti-Inflammatory Agents / pharmacology Disease Models, Animal Inflammation / etiology Locomotion / drug effects Male Neuralgia / etiology Rats Rats, Sprague-Dawley Recovery of Function / drug effects Spinal Cord / drug effects Spinal Cord Injuries / complications Sumatriptan / pharmacology
Sumatriptan neuroinflammation neuropathic pain spinal cord injury

Journal

Neurological research
ISSN: 1743-1328
Titre abrégé: Neurol Res
Pays: England
ID NLM: 7905298

Informations de publication

Date de publication:
Jan 2021
Historique:
pubmed: 17 9 2020
medline: 14 10 2021
entrez: 16 9 2020
Statut: ppublish

Résumé

To investigate the therapeutic effects of sumatriptan in a rat model of spinal cord injury (SCI) and possible anti-inflammatory and analgesic mechanisms underlying this effect. Using an aneurysm mini-clip model of contusive SCI, T9-10 laminectomies were performed for 60 male rats. Animals were divided into six experimental groups ( Sumatriptan significantly ( Sumatriptan improves functional recovery from SCI through its anti-inflammatory effects and reducing pro-inflammatory and pain mediators.

Identifiants

DOI: 10.1080/01616412.2020.1819090 PMID: 32935647
pubmed: 32935647
doi: 10.1080/01616412.2020.1819090
doi:

Substances chimiques

Analgesics 0
Anti-Inflammatory Agents 0
Sumatriptan 8R78F6L9VO

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

29-39

Auteurs

Khashayar Afshari (K)

Experimental Medicine Research Center, Tehran University of Medical Sciences , Tehran, Iran.
Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences , Tehran, Iran.

Amir Dehdashtian (A)

Experimental Medicine Research Center, Tehran University of Medical Sciences , Tehran, Iran.
Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences , Tehran, Iran.
ORCID: 0000-0003-2617-4124

Nazgol-Sadat Haddad (NS)

Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences , Tehran, Iran.

Seyedeh Zarifeh Jazaeri (SZ)

Experimental Medicine Research Center, Tehran University of Medical Sciences , Tehran, Iran.

Daniel C Ursu (DC)

Department of Surgery, Section of Plastic and Reconstructive Surgery, University of Michigan , USA.
ORCID: 0000-0002-6579-103X

Mina Khalilzadeh (M)

Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences , Tehran, Iran.

Arvin Haj-Mirzaian (A)

Experimental Medicine Research Center, Tehran University of Medical Sciences , Tehran, Iran.
Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences , Tehran, Iran.

Saeed Shakiba (S)

Experimental Medicine Research Center, Tehran University of Medical Sciences , Tehran, Iran.
Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences , Tehran, Iran.

Terry C Burns (TC)

Department of Neurological Surgery, Mayo Clinic Rochester , USA.

Seyed Mohammad Tavangar (SM)

Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences , Tehran, Iran.
Department of Pathology, Dr. Shariati Hospital, Tehran University of Medical Sciences , Tehran, Iran.

Mehdi Ghasemi (M)

Department of Neurology, University of Massachusetts School of Medicine , Worcester, MA.
ORCID: 0000-0002-1384-9826

Ahmad Reza Dehpour (AR)

Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences , Tehran, Iran.
Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences , Tehran, Iran.
ORCID: 0000-0002-8001-5565

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Classifications MeSH

Recherchemedicale.com › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Analgésiques › Sumatriptan improves the locomotor activity...
Recherchemedicale.com › Eucaryotes › Animaux › Sumatriptan improves the locomotor activity...
Recherchemedicale.com › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Sumatriptan improves the locomotor activity...
Recherchemedicale.com › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Sumatriptan improves the locomotor activity...
Recherchemedicale.com › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Sumatriptan improves the locomotor activity...
Recherchemedicale.com › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Locomotion › Sumatriptan improves the locomotor activity...
Recherchemedicale.com › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Névralgie › Sumatriptan improves the locomotor activity...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Sumatriptan improves the locomotor activity...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Sumatriptan improves the locomotor activity...
Recherchemedicale.com › Phénomènes biologiques › Récupération fonctionnelle › Sumatriptan improves the locomotor activity...
Recherchemedicale.com › Système nerveux › Système nerveux central › Moelle spinale › Sumatriptan improves the locomotor activity...
Recherchemedicale.com › Plaies et blessures › Traumatismes de la moelle épinière › Sumatriptan improves the locomotor activity...
Recherchemedicale.com › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Tryptamines › Sumatriptan › Sumatriptan improves the locomotor activity...