The effect of probiotics on ıntestinal motility in an experimental short bowel model.

Animals Gastrointestinal Motility / drug effects Jejunum Muscle, Smooth Probiotics / pharmacology Rats Short Bowel Syndrome

Journal

Acta cirurgica brasileira
ISSN: 1678-2674
Titre abrégé: Acta Cir Bras
Pays: Brazil
ID NLM: 9103983

Informations de publication

Date de publication:
07 Sep 2020
Historique:
received: 21 04 2020
accepted: 24 07 2020
entrez: 9 9 2020
pubmed: 10 9 2020
medline: 15 9 2020
Statut: epublish

Résumé

To investigate the effect of probiotics on spontaneous contractions of smooth muscle isolated from jejunum and ileum of rat model. Four rat groups were created (n=8, in each) including control (Group 1), control+probiotic (Group 2), short bowel (Group 3), and short bowel+probiotic (Group 4). Groups 1 and 2 underwent sham operation, Groups 3 and 4 underwent massive bowel resection. Bifidobacterium Lactis was administered in Groups 2 and 4 daily (P.O.) for three weeks. On postoperative week 3, rats were sacrificed, and jejunum and ileum smooth muscle were isolated for organ bath. Muscle contraction changes were analyzed before and after addition of antagonists. Short bowel group exhibited increased amplitude and frequency of spontaneous contractions. The addition of probiotics significantly decreased enhanced amplitude and frequency of bowel contraction in short bowel group and returned to control values. L-NNA increased amplitude and frequency of contractions in all groups. While indomethacin and nimesulide increased the amplitude in all groups, the frequency was only increased in jejunum. Hexamethonium and tetrodotoxin did not change the contraction characteristics in all groups. We suggest that early use of probiotics may significantly regulate bowel motility, and accordingly improve absorption of nutrients in short bowel syndrome.

Identifiants

DOI: 10.1590/s0102-865020200080000004 PMID: 32901681 PMC: PMC7478466
pubmed: 32901681
pii: S0102-86502020000800203
doi: 10.1590/s0102-865020200080000004
pmc: PMC7478466
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e202000804

Références

Dig Dis Sci. 2001 Sep;46(9):2010-6
pubmed: 11575457
J Pediatr Gastroenterol Nutr. 2008 Oct;47(4):450-7
pubmed: 18852637
J Travel Med. 1997 Mar 1;4(1):41-43
pubmed: 9815476
Cir Pediatr. 2010 Apr;23(2):118-21
pubmed: 21298924
Gastroenterology. 2006 Mar;130(3):731-46
pubmed: 16530515
Gastroenterology. 2006 Feb;130(2 Suppl 1):S16-28
pubmed: 16473066
Am J Pathol. 2012 Feb;180(2):626-35
pubmed: 22155109
Dig Dis Sci. 2002 Mar;47(3):511-6
pubmed: 11911334
Eur J Clin Invest. 1993 Nov;23(11):724-8
pubmed: 7508398
Gastroenterology. 2001 Dec;121(6):1354-71
pubmed: 11729115
Gastroenterology. 1978 May;74(5 Pt 1):829-30
pubmed: 416989
J Pediatr Gastroenterol Nutr. 2006 May;42(5):545-52
pubmed: 16707979
J Pharmacol Exp Ther. 2006 Jun;317(3):938-45
pubmed: 16474005
Res Microbiol. 2005 Mar;156(2):256-62
pubmed: 15748992
J Pediatr Gastroenterol Nutr. 2000 Jan;30(1):54-60
pubmed: 10630440
J Int Med Res. 1989 Jul-Aug;17(4):333-8
pubmed: 2676650
Curr Opin Gastroenterol. 2005 Nov;21(6):697-701
pubmed: 16220048
Am J Physiol Gastrointest Liver Physiol. 2004 Apr;286(4):G613-26
pubmed: 15010363
World J Gastroenterol. 2006 Oct 7;12(37):5987-94
pubmed: 17009397
Lancet. 2003 Feb 8;361(9356):512-9
pubmed: 12583961
Anaerobe. 2008 Oct;14(4):229-33
pubmed: 18511310
J Pediatr Surg. 2002 May;37(5):699-702
pubmed: 11987081
Infect Immun. 2005 Aug;73(8):5183-8
pubmed: 16041036
Aliment Pharmacol Ther. 2003 Apr 1;17(7):895-904
pubmed: 12656692
Lancet. 1999 Aug 21;354(9179):635-9
pubmed: 10466665
Am J Surg. 1993 Jan;165(1):74-80
pubmed: 7678190
Aliment Pharmacol Ther. 1999 Aug;13(8):1103-8
pubmed: 10468688
Gastroenterology. 2007 Feb;132(2):562-75
pubmed: 17258729
Am J Clin Nutr. 2001 Feb;73(2 Suppl):430S-436S
pubmed: 11157353
Pediatr Surg Int. 2007 Mar;23(3):243-8
pubmed: 17205292
J Pediatr Gastroenterol Nutr. 2001 Oct;33 Suppl 2:S17-25
pubmed: 11698781
Gastroenterology. 2001 Sep;121(3):580-91
pubmed: 11522742
Am J Gastroenterol. 2000 May;95(5):1231-8
pubmed: 10811333
Gut. 1996 Aug;39(2):267-72
pubmed: 8977342
Gut. 2003 Jun;52(6):827-33
pubmed: 12740338
Clin Perinatol. 1996 Jun;23(2):377-86
pubmed: 8780910
N Engl J Med. 1992 Aug 20;327(8):511-5
pubmed: 1378938
Aliment Pharmacol Ther. 2001 Feb;15(2):163-9
pubmed: 11148433
Am J Dig Dis. 1976 Jul;21(7):542-6
pubmed: 821341
Clin Exp Immunol. 2008 Mar;151(3):528-35
pubmed: 18190603
J Pediatr Surg. 2004 Nov;39(11):1686-92
pubmed: 15547835
Neurogastroenterol Motil. 2004 Dec;16(6):785-99
pubmed: 15601429
J Pediatr Surg. 2007 Aug;42(8):1365-71
pubmed: 17706498
Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G315-22
pubmed: 16973917
Am J Physiol Cell Physiol. 2006 Apr;290(4):C1018-30
pubmed: 16306130
Cir Pediatr. 2002 Oct;15(4):162-5
pubmed: 12601975
Clin Vaccine Immunol. 2006 Feb;13(2):219-26
pubmed: 16467329
J Physiol. 2004 May 15;557(Pt 1):191-205
pubmed: 15020692
N Engl J Med. 1995 Nov 16;333(20):1360-1
pubmed: 7566045
Eur J Pediatr. 1989 Jan;148(4):294-9
pubmed: 2651129
Pediatr Surg Int. 2005 Dec;21(12):947-53
pubmed: 16267678
Am J Surg. 2011 Oct;202(4):461-8
pubmed: 21722874
Med Microbiol Immunol. 2001 Apr;189(3):147-52
pubmed: 11388612
Hepatology. 2007 Sep;46(3):841-50
pubmed: 17659579
Am J Gastroenterol. 1995 Mar;90(3):439-48
pubmed: 7872284
Gastroenterology. 2004 Feb;126(2):520-8
pubmed: 14762789
J Pediatr Gastroenterol Nutr. 2001 Apr;32(4):506-8
pubmed: 11396828
Gastroenterology. 2003 May;124(5):1202-9
pubmed: 12730861
J Med Microbiol. 2003 Oct;52(Pt 10):925-930
pubmed: 12972590
Gut. 2003 Jul;52(7):988-97
pubmed: 12801956
Exp Physiol. 2006 Jan;91(1):229-37
pubmed: 16263800
Pediatr Surg Int. 2011 Dec;27(12):1301-5
pubmed: 21748652
Am J Gastroenterol. 1996 Aug;91(8):1579-85
pubmed: 8759665
Res Microbiol. 2001 Oct;152(8):735-41
pubmed: 11686387
Gastroenterology. 1992 Dec;103(6):1928-49
pubmed: 1333429
Acta Paediatr Taiwan. 2007 Mar-Apr;48(2):89-92
pubmed: 17626609
Gastroenterology. 2000 Aug;119(2):305-9
pubmed: 10930365
Gut. 2004 Jan;53(1):108-14
pubmed: 14684584
Am J Gastroenterol. 2000 Jan;95(1 Suppl):S16-8
pubmed: 10634223
J Pediatr Gastroenterol Nutr. 2004 Mar;38(3):288-92
pubmed: 15076628
J Pediatr Gastroenterol Nutr. 1998 Aug;27(2):155-60
pubmed: 9702645
Clin Exp Immunol. 2006 Oct;146(1):109-15
pubmed: 16968405

Auteurs

Mehmet Metin (M)

MD, Department of Pediatric Surgery , Faculty of Medicine , Cumhuriyet University , Sivas , and Department of Pediatric Surgery , Hitit University Erol Olçok Training and Research Hospital , Corum , Turkey . Conception and design of the study, acquisition of data, statistical analysis, manuscript writing, critical revision, final approval.
ORCID: 0000-0002-3093-5435

Ahmet Altun (A)

MD, Department of Pharmacology , Faculty of Medicine , Cumhuriyet University , Sivas , Turkey . Conception and design of the study, acquisition of data, statistical analysis, manuscript writing.
ORCID: 0000-0003-2056-8683

Gökhan Köylüoğlu (G)

MD, Department of Pediatric Surgery , Faculty of Medicine , Cumhuriyet University , Sivas , Turkey . Critical revision, final approval.
ORCID: 0000-0002-1140-169X

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › The effect of probiotics on ıntestinal...
Recherchemedicale.com › Phénomènes physiologiques de l'appareil buccodentaire et de l'appareil digestif › Phénomènes physiologiques de l'appareil digestif › Motilité gastrointestinale › The effect of probiotics on ıntestinal...
Recherchemedicale.com › Système digestif › Tube digestif › Tube digestif inférieur › Jéjunum › The effect of probiotics on ıntestinal...
Recherchemedicale.com › Tissus › Muscles › Muscles lisses › The effect of probiotics on ıntestinal...
Recherchemedicale.com › Aliments et boissons › Aliments › Compléments alimentaires › Probiotiques › The effect of probiotics on ıntestinal...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › The effect of probiotics on ıntestinal...
Recherchemedicale.com › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Syndrome de l'intestin court › The effect of probiotics on ıntestinal...