In-cell architecture of the nuclear pore and snapshots of its turnover.

Autophagy Cryoelectron Microscopy Models, Molecular Nuclear Pore / chemistry Nuclear Pore Complex Proteins / metabolism Saccharomyces cerevisiae / cytology Saccharomyces cerevisiae Proteins / metabolism Tomography

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
10 2020
Historique:
received: 07 08 2019
accepted: 01 06 2020
pubmed: 4 9 2020
medline: 3 2 2021
entrez: 4 9 2020
Statut: ppublish

Résumé

Nuclear pore complexes (NPCs) fuse the inner and outer membranes of the nuclear envelope. They comprise hundreds of nucleoporins (Nups) that assemble into multiple subcomplexes and form large central channels for nucleocytoplasmic exchange

Identifiants

DOI: 10.1038/s41586-020-2670-5 PMID: 32879490
pubmed: 32879490
doi: 10.1038/s41586-020-2670-5
pii: 10.1038/s41586-020-2670-5
doi:

Substances chimiques

NUP116 protein, S cerevisiae 0
NUP159 protein, S cerevisiae 0
Nuclear Pore Complex Proteins 0
Saccharomyces cerevisiae Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

796-800

Subventions

Organisme : European Research Council
Pays : International

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Auteurs

Matteo Allegretti (M)

Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
ORCID: 0000-0002-9542-7482

Christian E Zimmerli (CE)

Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Collaboration for joint PhD degree between EMBL and Heidelberg University, Faculty of Biosciences, Heidelberg, Germany.

Vasileios Rantos (V)

Centre for Structural Systems Biology (CSSB), DESY and European Molecular Biology Laboratory, Hamburg, Germany.
ORCID: 0000-0003-4768-3091

Florian Wilfling (F)

Max Planck Institute of Biochemistry, Martinsried, Germany.
ORCID: 0000-0002-6559-7261

Paolo Ronchi (P)

Electron Microscopy Core Facility (EMCF), European Molecular Biology Laboratory, Heidelberg, Germany.

Herman K H Fung (HKH)

Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.

Chia-Wei Lee (CW)

Max Planck Institute of Biochemistry, Martinsried, Germany.
ORCID: 0000-0002-8925-7421

Wim Hagen (W)

Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
ORCID: 0000-0001-6229-2692

Beata Turoňová (B)

Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
ORCID: 0000-0002-5457-4478

Kai Karius (K)

Centre for Structural Systems Biology (CSSB), DESY and European Molecular Biology Laboratory, Hamburg, Germany.

Mandy Börmel (M)

Electron Microscopy Core Facility (EMCF), European Molecular Biology Laboratory, Heidelberg, Germany.
ORCID: 0000-0002-4354-891X

Xiaojie Zhang (X)

Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.

Christoph W Müller (CW)

Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
ORCID: 0000-0003-2176-8337

Yannick Schwab (Y)

Electron Microscopy Core Facility (EMCF), European Molecular Biology Laboratory, Heidelberg, Germany.
Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.

Julia Mahamid (J)

Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
ORCID: 0000-0001-6968-041X

Boris Pfander (B)

Max Planck Institute of Biochemistry, Martinsried, Germany. bpfander@biochem.mpg.de.
ORCID: 0000-0003-2180-5054

Jan Kosinski (J)

Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. jan.kosinski@embl.de.
Centre for Structural Systems Biology (CSSB), DESY and European Molecular Biology Laboratory, Hamburg, Germany. jan.kosinski@embl.de.
ORCID: 0000-0002-3641-0322

Martin Beck (M)

Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. martin.beck@biophys.mpg.de.
Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany. martin.beck@biophys.mpg.de.
Department of Molecular Sociology, Max Planck Institute of Biophysics, Frankfurt, Germany. martin.beck@biophys.mpg.de.
ORCID: 0000-0002-7397-1321

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Classifications MeSH

Recherchemedicale.com › Phénomènes physiologiques cellulaires › Autophagie › In-cell architecture of the nuclear pore and...
Recherchemedicale.com › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › In-cell architecture of the nuclear pore and...
Recherchemedicale.com › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › In-cell architecture of the nuclear pore and...
Recherchemedicale.com › Cellules › Structures cellulaires › Espace intracellulaire › Structures nucléaires › Pore nucléaire › In-cell architecture of the nuclear pore and...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs nucléocytoplasmiques › Complexe protéique du pore nucléaire › In-cell architecture of the nuclear pore and...
Recherchemedicale.com › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › In-cell architecture of the nuclear pore and...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Saccharomyces cerevisiae › In-cell architecture of the nuclear pore and...
Recherchemedicale.com › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › In-cell architecture of the nuclear pore and...