Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patients.
C-reactive protein
COVID-19
Case mortality ratio
Cytokine storm
SARS-CoV-2
Vitamin D
Journal
Aging clinical and experimental research
ISSN: 1720-8319
Titre abrégé: Aging Clin Exp Res
Pays: Germany
ID NLM: 101132995
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
20
06
2020
accepted:
04
08
2020
pubmed:
3
9
2020
medline:
21
10
2020
entrez:
3
9
2020
Statut:
ppublish
Résumé
We present evidence for a possible role of Vitamin D (VitD) deficiency in unregulated cytokine production and inflammation leading to complications in COVID-19 patients. The time-adjusted case mortality ratio (T-CMR) was estimated as the ratio of deceased patients on day N to the confirmed cases on day N-8. The adaptive average of T-CMR (A-CMR) was calculated as a metric of COVID-19 associated mortality. A model based on positivity change (PC) and an estimated prevalence of COVID-19 was used to determine countries with similar screening strategies. A possible association of A-CMR with the mean concentration of 25-hydroxyvitamin D (25(OH)D) in elderly individuals in countries with similar screening strategy was investigated. We considered high C-reactive protein (CRP) in severe COVID-19 patients (CRP ≥ 1 mg/dL) as a surrogate of a cytokine storm. We considered high-sensitivity CRP (hs-CRP) in healthy subjects as hs-CRP ≥ 0.2 mg/dL. A link between 25(OH)D and A-CMR in countries with similar screening strategy is evidence for VitD's possible role in reducing unregulated cytokine production and inflammation among patients with severe COVID-19. We observed an odds ratio (OR) of 1.8 with 95% confidence interval (95% CI) (1.2 to 2.6) and an OR of 1.9 with 95% CI (1.4 to 2.7) for hs-CRP in VitD deficient elderly from low-income families and high-income families, respectively. COVID-19 patient-level data show an OR of 3.4 with 95% CI (2.15 to 5.4) for high CRP in severe COVID-19 patients. We conclude that future studies on VitD's role in reducing cytokine storm and COVID-19 mortality are warranted.
Identifiants
pubmed: 32876941
doi: 10.1007/s40520-020-01677-y
pii: 10.1007/s40520-020-01677-y
pmc: PMC7465887
doi:
Substances chimiques
Cytokines
0
Vitamin D
1406-16-2
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2141-2158Subventions
Organisme : NCI NIH HHS
ID : R01 CA225002
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : ErratumIn
Références
Inflamm Allergy Drug Targets. 2013 Aug;12(4):239-45
pubmed: 23782205
Intern Emerg Med. 2013 Feb;8(1):33-40
pubmed: 21437585
Semin Arthritis Rheum. 1990 Dec;20(3):129-47
pubmed: 1705051
Nutrients. 2016 Dec 12;8(12):
pubmed: 27973447
Bone. 2008 Feb;42(2):267-70
pubmed: 18024243
Crit Care Med. 2020 May;48(5):654-662
pubmed: 31923030
Ann Nutr Metab. 2018;73(1):62-73
pubmed: 29945132
Intensive Care Med. 2012 Oct;38(10):1647-53
pubmed: 22777516
Eur J Clin Nutr. 2011 Mar;65(3):321-8
pubmed: 21179052
Blood. 2014 Jul 10;124(2):188-95
pubmed: 24876563
Int J Clin Exp Med. 2015 Oct 15;8(10):18302-10
pubmed: 26770432
Nutrients. 2020 May 09;12(5):
pubmed: 32397511
Commun Biol. 2019 Aug 5;2:288
pubmed: 31396568
BMC Public Health. 2015 Jul 11;15:641
pubmed: 26162848
Dermatoendocrinol. 2009 Jul;1(4):215-9
pubmed: 20592793
Int J Epidemiol. 2008 Feb;37(1):113-9
pubmed: 18245055
Clin Cardiol. 2019 Jul;42(7):663-669
pubmed: 31020672
bioRxiv. 2020 Nov 04;:
pubmed: 33140054
Lancet. 1995 Jul 22;346(8969):207-10
pubmed: 7616799
Tohoku J Exp Med. 2011;223(3):153-9
pubmed: 21350317
BMJ. 2020 Mar 27;368:m1185
pubmed: 32220865
Pediatrics. 2013 Oct;132(4):e832-40
pubmed: 24019420
Front Immunol. 2019 Feb 08;10:65
pubmed: 30800121
Am J Med. 2010 Apr;123(4):335-41
pubmed: 20362753
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Cell Immunol. 2009;258(1):18-28
pubmed: 19345936
Clin Epidemiol. 2020 Dec 08;12:1337-1346
pubmed: 33335428
Endocrine. 2016 Aug;53(2):543-50
pubmed: 27106800
Metabolism. 2014 Aug;63(8):1056-62
pubmed: 24928661
Mov Disord. 2020 Jul;35(7):1089-1093
pubmed: 32484584
Front Immunol. 2018 Mar 05;9:320
pubmed: 29556226
Lancet Infect Dis. 2020 Jul;20(7):773
pubmed: 32171390
PLoS One. 2012;7(4):e34950
pubmed: 22539952
Eur J Heart Fail. 2011 Jun;13(6):619-25
pubmed: 21543375
Proc Natl Acad Sci U S A. 2020 May 5;117(18):9696-9698
pubmed: 32300018
Clin Rheumatol. 2016 Jul;35(7):1865-72
pubmed: 25994612
Science. 2020 May 1;368(6490):473-474
pubmed: 32303591
Aliment Pharmacol Ther. 2020 Jul;52(2):412-413
pubmed: 32402109
Eur J Nutr. 2013 Jun;52(4):1405-15
pubmed: 23015061
Sci Rep. 2019 Nov 13;9(1):16719
pubmed: 31723229
Clin Nutr. 2016 Dec;35(6):1251-1258
pubmed: 27161894
Medicine (Baltimore). 2018 Jun;97(26):e11032
pubmed: 29952942
JAMA. 2016 Jan 26;315(4):362-70
pubmed: 26813209
Exp Gerontol. 2008 Aug;43(8):718-28
pubmed: 18586079
J Pharmacol Pharmacother. 2012 Oct;3(4):300-3
pubmed: 23326099
Eur J Clin Nutr. 2010 Feb;64(2):203-9
pubmed: 19953106
Kidney Int. 1998 Nov;54(5):1463-9
pubmed: 9844122
Iran J Public Health. 2019 Apr;48(4):644-654
pubmed: 31110974
J Clin Invest. 2003 Jun;111(12):1805-12
pubmed: 12813013
Lancet. 2016 Apr 9;387(10027):1513-1530
pubmed: 27061677
Microbiol Immunol. 2010 Sep;54(9):542-50
pubmed: 20840153
Natl Sci Rev. 2020 Jun;7(6):1012-1023
pubmed: 34676127
PLoS One. 2013 Jun 19;8(6):e65835
pubmed: 23840373
Int J Endocrinol. 2010;2010:
pubmed: 20871847
JAMA. 2020 May 12;323(18):1775-1776
pubmed: 32203977
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Biol Neonate. 2001 Feb;79(2):103-8
pubmed: 11223651
Lancet. 2017 Jan 7;389(10064):37-55
pubmed: 27863813
Am J Clin Nutr. 2020 May 1;111(5):1036-1047
pubmed: 32232398
Sci Rep. 2019 Dec 23;9(1):19713
pubmed: 31873182
J Frailty Aging. 2013;2(4):174-8
pubmed: 27070922
Am J Clin Nutr. 1992 Sep;56(3):537-42
pubmed: 1503066
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
J Investig Med. 2011 Aug;59(6):881-6
pubmed: 21527855
PLoS One. 2015 Sep 15;10(9):e0138613
pubmed: 26372355
J Inflamm Res. 2014 May 29;7:69-87
pubmed: 24971027
Curr Immunol Rev. 2011 Feb 1;7(1):104-115
pubmed: 21461315
Front Nutr. 2019 Oct 23;6:166
pubmed: 31709259
BMJ. 2017 Feb 15;356:i6583
pubmed: 28202713
MMWR Morb Mortal Wkly Rep. 2020 Mar 27;69(12):343-346
pubmed: 32214079
J Health Popul Nutr. 2011 Apr;29(2):149-55
pubmed: 21608424
Lancet. 2017 Dec 16;390(10113):2627-2642
pubmed: 29029897
Nat Med. 2020 Apr;26(4):506-510
pubmed: 32284616
Age Ageing. 2013 May;42(3):404-8
pubmed: 23542723
J Clin Virol. 2020 Jun;127:104378
pubmed: 32353762
BMJ. 2020 May 22;369:m1985
pubmed: 32444460