Diabetic Cataract in Spontaneously Diabetic Torii Fatty Rats.
Animals
Body Weight
Cataract
/ diagnosis
Diabetes Mellitus, Experimental
/ complications
Diabetes Mellitus, Type 2
/ complications
Diabetic Retinopathy
/ diagnosis
Disease Models, Animal
Disease Progression
Humans
Male
Obesity
/ complications
Oxidative Stress
/ physiology
Rats
Rats, Sprague-Dawley
Slit Lamp Microscopy
Journal
Journal of diabetes research
ISSN: 2314-6753
Titre abrégé: J Diabetes Res
Pays: England
ID NLM: 101605237
Informations de publication
Date de publication:
2020
2020
Historique:
received:
15
05
2020
revised:
09
07
2020
accepted:
17
07
2020
entrez:
25
8
2020
pubmed:
25
8
2020
medline:
3
7
2021
Statut:
epublish
Résumé
Spontaneously Diabetic Torii (SDT) fatty rat is a novel animal model of type 2 diabetes with obesity. SDT fatty rats develop hyperglycemia, dyslipidemia, and other diabetic complications including ocular disorders; however, diabetic cataract formation in SDT fatty rats has not been fully investigated. The aim of the current study was to investigate the characteristics of cataract in the SDT fatty rats. The mean body weight of SDT fatty rats is larger than that of age-matched Sprague-Dawley (SD) rats and control animals until 8 weeks of age, and thereafter the growing speed decreased until the end of observation at 16 weeks of age. Blood glucose levels in SDT fatty rats were significantly higher than those in SD rats throughout the observational period. Slit-lamp examination revealed that no rats showed cataract formation at 5 weeks of age; however, SDT fatty rats gradually developed cortical cataract and posterior subcapsular cataract, both of which are the common types of cataract in patients with type 2 diabetes. The levels of glucose, sorbitol, and fructose were higher in the lens tissues of SDT fatty rats in comparison with that of SD rats. Furthermore, the level of 4-hydroxynonenal (4-HNE) was higher in the lens of SDT fatty rats than in that of SD rats. By contrast, total glutathione (GSH) concentration was lower in the lens of SDT fatty rats than in that of SD rats. The present study demonstrated that the cataractogenesis in SDT fatty rats resembled human diabetic cataract formation, indicating that SDT fatty rats serve as a potential animal model in researches on human cataract associated with type 2 diabetes and obesity.
Identifiants
pubmed: 32832559
doi: 10.1155/2020/3058547
pmc: PMC7422424
doi:
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3058547Informations de copyright
Copyright © 2020 Kasumi Kikuchi et al.
Déclaration de conflit d'intérêts
The authors KY and SM are employees of CLEA Japan, Inc. The other authors declare that there are no conflicts of interest regarding the publication of this paper.
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