Clostridium perfringens α-toxin specifically induces endothelial cell death by promoting ceramide-mediated apoptosis.
Animals
Apoptosis
Bacterial Toxins
/ metabolism
Calcium-Binding Proteins
/ metabolism
Cell Death
Cell Line
Cells, Cultured
Ceramides
/ metabolism
Clostridium Infections
/ metabolism
Clostridium perfringens
/ pathogenicity
Endothelial Cells
/ metabolism
Gas Gangrene
/ metabolism
Host-Pathogen Interactions
Humans
Mice
Type C Phospholipases
/ metabolism
Apoptosis
Clostridium perfringens α-toxin
Endothelial cell death
Journal
Anaerobe
ISSN: 1095-8274
Titre abrégé: Anaerobe
Pays: England
ID NLM: 9505216
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
08
05
2020
revised:
14
07
2020
accepted:
17
08
2020
pubmed:
24
8
2020
medline:
23
6
2021
entrez:
24
8
2020
Statut:
ppublish
Résumé
Clostridium perfringens type A-induced gas gangrene is characterized by severe myonecrosis, and α-toxin has been revealed to be a major virulence factor involved in the pathogenesis. However, the detailed mechanism is unclear. Here, we show that CD31
Identifiants
pubmed: 32828915
pii: S1075-9964(20)30118-9
doi: 10.1016/j.anaerobe.2020.102262
pii:
doi:
Substances chimiques
Bacterial Toxins
0
Calcium-Binding Proteins
0
Ceramides
0
Type C Phospholipases
EC 3.1.4.-
alpha toxin, Clostridium perfringens
EC 3.1.4.3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102262Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.