A Clinical Tool to Predict Low Serum Selenium in Patients with Worsening Heart Failure.
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Disease Progression
Female
Heart Failure
/ etiology
Humans
Iron Deficiencies
Kidney
/ physiopathology
Male
Micronutrients
Middle Aged
Natriuretic Peptide, Brain
/ blood
Peptide Fragments
/ blood
Predictive Value of Tests
Prognosis
Quality of Life
Risk Factors
Selenium
/ blood
Serum Albumin
/ deficiency
Young Adult
albumin
heart failure
iron deficiency
malnutrition
selenium
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
21 Aug 2020
21 Aug 2020
Historique:
received:
29
05
2020
revised:
15
08
2020
accepted:
17
08
2020
entrez:
23
8
2020
pubmed:
23
8
2020
medline:
7
4
2021
Statut:
epublish
Résumé
Selenium is an essential micronutrient, and a low selenium concentration (<100 µg/L) is associated with a poorer quality of life and exercise capacity, and an impaired prognosis in patients with worsening heart failure. Measuring selenium concentrations routinely is laborious and costly, and although its clinical utility is yet to be proven, an easy implemented model to predict selenium status is desirable. A stepwise multivariable logistic regression analysis was performed using routinely measured clinical factors. Low selenium was independently predicted by: older age, lower serum albumin, higher N-terminal pro-B-type natriuretic peptide levels, worse kidney function, and the presence of orthopnea and iron deficiency. A 10-points risk-model was developed, and a score of ≥6 points identified >80% of patients with low selenium (sensitivity of 44%, specificity of 80%). Given that selenium and iron overlap in their physiological roles, we evaluated the shared determinants and prognostic associates. Both deficiencies shared similar clinical characteristics, including the model risk factors and, in addition, a low protein intake and high levels of C-reactive protein. Low selenium was associated with a similar or worse prognosis compared to iron deficiency. In conclusion, although it is difficult to exclude low selenium based on clinical characteristics alone, we provide a prediction tool which identifies heart failure patients at higher risk of having a low selenium status.
Identifiants
pubmed: 32825781
pii: nu12092541
doi: 10.3390/nu12092541
pmc: PMC7551091
pii:
doi:
Substances chimiques
Micronutrients
0
Peptide Fragments
0
Serum Albumin
0
pro-brain natriuretic peptide (1-76)
0
Natriuretic Peptide, Brain
114471-18-0
Selenium
H6241UJ22B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fourth Framework Programme
ID : FP7-242209-BIOSTAT-CHF
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