Temporal and Spatial Heterogeneity of Host Response to SARS-CoV-2 Pulmonary Infection.
Journal
medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986
Informations de publication
Date de publication:
02 Aug 2020
02 Aug 2020
Historique:
entrez:
9
8
2020
pubmed:
9
8
2020
medline:
9
8
2020
Statut:
epublish
Résumé
The relationship of SARS-CoV-2 lung infection and severity of pulmonary disease is not fully understood. We analyzed autopsy specimens from 24 patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein analytical platforms to characterize inter- and intra- patient heterogeneity of pulmonary virus infection. There was a spectrum of high and low virus cases that was associated with duration of disease and activation of interferon pathway genes. Using a digital spatial profiling platform, the virus corresponded to distinct spatial expression of interferon response genes and immune checkpoint genes demonstrating the intra-pulmonary heterogeneity of SARS-CoV-2 infection.
Identifiants
pubmed: 32766600
doi: 10.1101/2020.07.30.20165241
pmc: PMC7402055
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI081848
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA240924
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA207021
Pays : United States
Commentaires et corrections
Type : UpdateIn
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