[Efficacy of different doses and timing of tranexamic acid in major orthopedic surgeries: a randomized trial].
Eficácia de diferentes doses e esquemas de administração de ácido tranexâmico em cirurgias ortopédicas de grande porte: estudo randomizado.
Adult
Aged
Antifibrinolytic Agents
/ administration & dosage
Blood Loss, Surgical
/ prevention & control
Blood Transfusion
/ statistics & numerical data
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Female
Humans
Male
Middle Aged
Orthopedic Procedures
/ methods
Postoperative Hemorrhage
/ prevention & control
Prospective Studies
Tranexamic Acid
/ administration & dosage
Blood loss
Blood transfusion
Dosage
Dosagem
Perda sanguínea
Posologia
Timing
Tranexamic acid
Transfusão de sangue
Ácido tranexâmico
Journal
Brazilian journal of anesthesiology (Elsevier)
ISSN: 2352-2291
Titre abrégé: Braz J Anesthesiol
Pays: Brazil
ID NLM: 101624623
Informations de publication
Date de publication:
Historique:
received:
26
06
2019
revised:
23
01
2020
accepted:
20
03
2020
pubmed:
6
8
2020
medline:
23
7
2021
entrez:
6
8
2020
Statut:
ppublish
Résumé
Tranexamic acid was studied in four different dosage regimens and their efficacy was compared for perioperative blood loss reduction, blood transfusion requirements and deep vein thrombosis (DVT) complication. Two hundred patients undergoing major orthopedic procedures were divided into five groups containing 40 each: placebo, low dose (bolus 10mg.kg The intraoperative blood loss was 440±207.54mL in the placebo group, 412.5±208.21mL in the low dose group, 290±149.6ml in the low dose plus maintenance group, 332.5±162.33mL in the high dose group and 240.7±88.15mL in the high dose maintenance group (p <0.001). The reduction in postoperative blood loss in the drain for the first 24hours was 80±44.44mL in the placebo group, 89.88±44.87mL in the low dose group, 56.7±29.12mL in the low dose plus maintenance group, 77.9±35.74mL in the high dose group and 46.7±19.9mL in the high dose maintenance group (p <0.001). DVT was not encountered in any patient. Tranexamic acid was most effective in reducing surgical blood loss and blood transfusion requirements in a low dose+maintenance group.
Sections du résumé
BACKGROUND
BACKGROUND
Tranexamic acid was studied in four different dosage regimens and their efficacy was compared for perioperative blood loss reduction, blood transfusion requirements and deep vein thrombosis (DVT) complication.
METHODS
METHODS
Two hundred patients undergoing major orthopedic procedures were divided into five groups containing 40 each: placebo, low dose (bolus 10mg.kg
RESULTS
RESULTS
The intraoperative blood loss was 440±207.54mL in the placebo group, 412.5±208.21mL in the low dose group, 290±149.6ml in the low dose plus maintenance group, 332.5±162.33mL in the high dose group and 240.7±88.15mL in the high dose maintenance group (p <0.001). The reduction in postoperative blood loss in the drain for the first 24hours was 80±44.44mL in the placebo group, 89.88±44.87mL in the low dose group, 56.7±29.12mL in the low dose plus maintenance group, 77.9±35.74mL in the high dose group and 46.7±19.9mL in the high dose maintenance group (p <0.001). DVT was not encountered in any patient.
CONCLUSION
CONCLUSIONS
Tranexamic acid was most effective in reducing surgical blood loss and blood transfusion requirements in a low dose+maintenance group.
Identifiants
pubmed: 32753113
pii: S0034-7094(20)30346-9
doi: 10.1016/j.bjan.2020.03.013
pmc: PMC9373493
pii:
doi:
Substances chimiques
Antifibrinolytic Agents
0
Tranexamic Acid
6T84R30KC1
Types de publication
Comparative Study
Journal Article
Randomized Controlled Trial
Langues
por
Sous-ensembles de citation
IM
Pagination
311-317Informations de copyright
Copyright © 2020 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.
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