Vitamin K
Animals
Apoptosis
/ drug effects
Autophagy
/ drug effects
Carcinoma, Hepatocellular
/ drug therapy
Cell Aggregation
/ drug effects
Cell Survival
/ drug effects
Dose-Response Relationship, Drug
HCT116 Cells
HEK293 Cells
Histone Deacetylase 6
/ antagonists & inhibitors
Histone Deacetylase Inhibitors
/ chemistry
Humans
Liver Neoplasms
/ drug therapy
MCF-7 Cells
Vitamin K 3
/ chemistry
Xenograft Model Antitumor Assays
/ methods
Zebrafish
Drug development
Epigenetics
HDAC6
Vitamin K(3)
Zebrafish
Journal
Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
10
04
2020
revised:
21
07
2020
accepted:
22
07
2020
pubmed:
30
7
2020
medline:
1
1
2021
entrez:
30
7
2020
Statut:
ppublish
Résumé
Epigenetics plays a vital role in regulating gene expression and determining the specific phenotypes of eukaryotic cells. Histone deacetylases (HDACs) are important epigenetic regulatory proteins effecting multiple biological functions. Particularly, HDAC6 has become a promising anti-cancer drug target because of its regulation of cell mobility, protein trafficking, degradation of misfolded proteins, cell growth, apoptosis, and metastasis. In this study, we identified one out of six vitamin K
Identifiants
pubmed: 32721508
pii: S0006-2952(20)30412-3
doi: 10.1016/j.bcp.2020.114176
pii:
doi:
Substances chimiques
Histone Deacetylase Inhibitors
0
Vitamin K 3
723JX6CXY5
HDAC6 protein, human
EC 3.5.1.98
Histone Deacetylase 6
EC 3.5.1.98
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
114176Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.