Survival benefit of accepting kidneys from older donation after cardiac death donors.
Scientific Registry for Transplant Recipients (SRTR)
clinical decision-making
clinical research/practice
donors and donation: donation after circulatory death (DCD)
epidemiology
health services and outcomes research
kidney transplantation/nephrology
organ procurement and allocation
patient survival
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
08
05
2020
revised:
16
06
2020
accepted:
01
07
2020
pubmed:
14
7
2020
medline:
22
6
2021
entrez:
14
7
2020
Statut:
ppublish
Résumé
Kidneys from older (age ≥50 years) donation after cardiac death (DCD50) donors are less likely to be transplanted due to inferior posttransplant outcomes. However, candidates who decline a DCD50 offer must wait for an uncertain future offer. To characterize the survival benefit of accepting DCD50 kidneys, we used 2010-2018 Scientific Registry for Transplant Recipients (SRTR) data to identify 92 081 adult kidney transplantation candidates who were offered a DCD50 kidney that was eventually accepted for transplantation. DCD50 kidneys offered to candidates increased from 590 in 2010 to 1441 in 2018. However, 34.6% of DCD50 kidneys were discarded. Candidates who accepted DCD50 offers had 49% decreased mortality risk (adjusted hazard ratio [aHR]
Identifiants
pubmed: 32659036
doi: 10.1111/ajt.16198
pmc: PMC8547550
mid: NIHMS1624829
pii: S1600-6135(22)08448-9
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1138-1146Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM136577
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23DK115908
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01 DK101677
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23 DK115908
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01DK101677
Pays : United States
Organisme : NIDDK NIH HHS
ID : K24 DK101828
Pays : United States
Organisme : NIDDK NIH HHS
ID : K24DK101828
Pays : United States
Informations de copyright
© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.
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